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Our previous study disclosed that aryloxy\u2010phenylpiperazine skeleton was a promising molecule to suppress\n                    <jats:italic>C. albicans<\/jats:italic>\n                    virulence by inhibiting hypha formation and biofilm formation. In order to deeply understand the efficacy and mechanism of action of phenylpiperazine compounds, and obtain new derivatives with excellent activity against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    , hence, we synthesized three series of (1\u2010heteroaryloxy\u20102\u2010hydroxypropyl)\u2010phenylpiperazines and evaluated their inhibitory activity against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    both in vitro and in vivo in this study. Compared with previously reported aryloxy\u2010phenylpiperazines, part of these heteroaryloxy derivatives improved their activities by strongly suppressing hypha formation and biofilm formation in\n                    <jats:italic>C. albicans<\/jats:italic>\n                    SC5314. Especially, (9H\u2010carbazol\u20104\u2010yl)oxy derivatives\n                    <jats:bold>25<\/jats:bold>\n                    ,\n                    <jats:bold>26<\/jats:bold>\n                    ,\n                    <jats:bold>27<\/jats:bold>\n                    and\n                    <jats:bold>28<\/jats:bold>\n                    exhibited strong activity in reducing\n                    <jats:italic>C. albicans<\/jats:italic>\n                    virulence in both human cell lines in vitro and mouse infection models in vivo. The compound\n                    <jats:bold>27<\/jats:bold>\n                    attenuated the virulence of various clinical\n                    <jats:italic>C. albicans<\/jats:italic>\n                    strains, including clinical drug\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    strains. Moreover, additive effects of the compound\n                    <jats:bold>27<\/jats:bold>\n                    with antifungal drugs against drug\u2010resistant\n                    <jats:italic>C. albicans<\/jats:italic>\n                    strains were also discussed. Furthermore, the compound\n                    <jats:bold>27<\/jats:bold>\n                    significantly improved the composition and richness of the faecal microbiota in mice infected by\n                    <jats:italic>C. albicans<\/jats:italic>\n                    . These findings indicate that these piperazine compounds have great potential to be developed as new therapeutic drugs against\n                    <jats:italic>C. albicans<\/jats:italic>\n                    infection.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.14169","type":"journal-article","created":{"date-parts":[[2022,11,21]],"date-time":"2022-11-21T00:59:40Z","timestamp":1668992380000},"page":"116-127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Anti\u2010virulence activity of novel (1\u2010heteroaryloxy\u20102\u2010hydroxypropyl)\u2010 phenylpiperazine derivatives against both wild\u2010type and clinical drug\u2010resistant\n                    <i>Candida albicans<\/i>\n                    strains"],"prefix":"10.1111","volume":"16","author":[{"given":"Junjun","family":"Huang","sequence":"first","affiliation":[{"name":"Guangzhou Municipal and Guangdong Provincial Key Laboratory of Molecular 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