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The current study aimed to evaluate the effects of HKC in the modulation of gut microbiota and the amelioration of metabolite levels by using non\u2010obese diabetes (NOD) mice with DN. The microbiota from three parts of intestines (duodenum, ileum and colon) in NOD mice with and without HKC treatment were analysed using 16S rDNA sequencing techniques. Untargeted metabolomics in plasma of NOD mice were analysed with liquid mass spectrometry. Results showed that HKC administration ameliorated DN in NOD mice and the flora in duodenum were more sensitive to HKC intervention, while the flora in colon had more effects on metabolism. The bacterial genera such as\n                    <jats:italic>Faecalitalea<\/jats:italic>\n                    and\n                    <jats:italic>Muribaculum<\/jats:italic>\n                    significantly increased and negatively correlated with most of the altered metabolites after HKC treatment, while\n                    <jats:italic>Phyllobacterium<\/jats:italic>\n                    ,\n                    <jats:italic>Weissella<\/jats:italic>\n                    and\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    showed an opposite trend. The plasma metabolites, mainly including amino acids and fatty acids such as methionine sulfoxide, BCAAs and cis\u20107\u2010Hexadecenoic acid, exhibited a distinct return to normal after HKC treatment. The current study thereby provides experimental evidence suggesting that HKC may modulate gut microbiota and subsequently ameliorate the metabolite levels in DN.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.14200","type":"journal-article","created":{"date-parts":[[2022,12,30]],"date-time":"2022-12-30T06:33:45Z","timestamp":1672382025000},"page":"813-826","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["<i>Abelmoschus Manihot<\/i>\n                    ameliorates the levels of circulating metabolites in diabetic nephropathy by modulating gut microbiota in non\u2010obese diabetes mice"],"prefix":"10.1111","volume":"16","author":[{"given":"Ruiya","family":"Shi","sequence":"first","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing 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