{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:04:05Z","timestamp":1776125045501,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T00:00:00Z","timestamp":1674691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The worldwide demand for reduced and restricted use of pesticides in agriculture due to serious environmental effects, health risks and the development of pathogen resistance calls for the discovery of new bioactive compounds. In the medical field, antibiotic\u2010resistant microorganisms have become a major threat to man, increasing mortality. Endophytes are endosymbiotic microorganisms that inhabit plant tissues without causing any visible damage to their host. Many endophytes secrete secondary metabolites with biological activity against a broad range of pathogens, making them potential candidates for novel drugs and alternative pesticides of natural origin. We isolated endophytes from wild plants in Israel, focusing on endophytes that secrete secondary metabolites with biological activity. We isolated 302 different endophytes from 30 different wild plants; 70 of them exhibited biological activity against phytopathogens. One biologically active fungal endophyte from the genus\n                    <jats:italic>Penicillium<\/jats:italic>\n                    , isolated from a squill (\n                    <jats:italic>Urginea maritima<\/jats:italic>\n                    ) leaf, was further examined. Chloroform\u2010based extraction of its growth medium was similarly active against phytopathogens. High\u2010performance liquid chromatography separation followed by gas chromatography\/mass spectrometry analysis revealed a single compound\u2014mycophenolic acid\u2014as the main contributor to the biological activity of the organic extract.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.14203","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T04:02:29Z","timestamp":1674705749000},"page":"1629-1638","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Endophytic\n                    <i>Penicillium<\/i>\n                    species secretes mycophenolic acid that inhibits the growth of phytopathogenic fungi"],"prefix":"10.1111","volume":"16","author":[{"given":"Neri","family":"Azar","sequence":"first","affiliation":[{"name":"Department of Plant Pathology and Weed Research ARO \u2013 the Volcani Center  Rishon LeZion 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