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Compounding this major health issue is the lack of antibiotic discovery and development, with only two new classes of antibiotics approved for clinical use in the last 20\u2009years. Combined efforts from the scientific community have reacted to the threat of dwindling treatment options to combat\n                    <jats:italic>S. aureus<\/jats:italic>\n                    disease in several innovative and exciting developments. This review describes current and future antimicrobial strategies aimed at treating staphylococcal colonization and\/or disease, examining therapies that show significant promise at the preclinical development stage to approaches that are currently being investigated in clinical trials.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.14268","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T10:48:22Z","timestamp":1683974902000},"page":"1456-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Novel antimicrobial strategies to treat multi\u2010drug resistant\n                    <i>Staphylococcus aureus<\/i>\n                    infections"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5892-8539","authenticated-orcid":false,"given":"Edward J. 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