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In this study, we have analysed C57BL\/6 mice under three feeding conditions: (i) a low\u2010fat diet group (LP), (ii) a high\u2010fat diet group (HP) and (iii) a high\u2010fat diet group supplemented with\n                    <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    (HA). The results found that\n                    <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    administration relieved weight gain, hepatic steatosis and liver injury induced by the high\u2010fat diet.\n                    <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    altered the gut microbiota with a decrease in\n                    <jats:italic>Alistipes<\/jats:italic>\n                    ,\n                    <jats:italic>Lactobacilli<\/jats:italic>\n                    ,\n                    <jats:italic>Tyzzerella<\/jats:italic>\n                    ,\n                    <jats:italic>Butyricimonas<\/jats:italic>\n                    and\n                    <jats:italic>Blautia<\/jats:italic>\n                    , and an enrichment of\n                    <jats:italic>Ruminiclostridium<\/jats:italic>\n                    ,\n                    <jats:italic>Osclibacter<\/jats:italic>\n                    ,\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    ,\n                    <jats:italic>Anaeroplasma<\/jats:italic>\n                    and\n                    <jats:italic>Rikenella<\/jats:italic>\n                    . The gut microbiota changes correlated significantly with bile acids. Meanwhile,\n                    <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    also improved glucose tolerance, gut barriers and adipokines dysbiosis.\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    regulated the intestinal FXR\u2010FGF15 axis and reshaped the construction of bile acids, with reduced secondary bile acids in the caecum and liver, including DCA and LCA. These findings provide new insights into the relationships between probiotics, microflora and metabolic disorders, highlighting the potential role of\n                    <jats:italic>A.\u2009muciniphila<\/jats:italic>\n                    in the management of MAFLD.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.14293","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T08:55:33Z","timestamp":1687942533000},"page":"1924-1939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":135,"title":["<i>Akkermansia muciniphila<\/i>\n                    alleviates\n                    <scp>high\u2010fat\u2010diet<\/scp>\n                    \u2010related metabolic\u2010associated fatty liver disease by modulating gut microbiota and bile acids"],"prefix":"10.1111","volume":"16","author":[{"given":"Wenrui","family":"Wu","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Kaicen","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Bian","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and 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