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For this reason, living organisms have developed different strategies and mechanisms to optimally regulate iron acquisition, transport, storage, and uptake in different environmental responses. Moreover, iron plays an essential role during microbial infections.\n                    <jats:italic>Saccharomyces cerevisiae<\/jats:italic>\n                    has been of key importance for decrypting iron homeostasis and regulation mechanisms in eukaryotes. Specifically, the transcription factors Aft1\/Aft2 and Yap5 regulate the expression of genes to control iron metabolism in response to its deficiency or excess, adapting to the cell's iron requirements and its availability in the environment. We also review which iron\u2010related virulence factors have the most common fungal human pathogens (\n                    <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                    ,\n                    <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    , and\n                    <jats:italic>Candida albicans<\/jats:italic>\n                    ). These factors are essential for adaptation in different host niches during pathogenesis, including different fungal\u2010specific iron\u2010uptake mechanisms. While being necessary for virulence, they provide hope for developing novel antifungal treatments, which are currently scarce and usually toxic for patients. In this review, we provide a compilation of the current knowledge about the metabolic response to iron deficiency and excess in fungi.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.14346","type":"journal-article","created":{"date-parts":[[2023,10,8]],"date-time":"2023-10-08T14:44:06Z","timestamp":1696776246000},"page":"2053-2071","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Regulatory and pathogenic mechanisms in response to iron deficiency and excess in fungi"],"prefix":"10.1111","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0350-6376","authenticated-orcid":false,"given":"Jordi","family":"Pijuan","sequence":"first","affiliation":[{"name":"Laboratory of Neurogenetics and Molecular Medicine Institut de Recerca Sant Joan de D\u00e9u  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), ISCIII  Madrid 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