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In this study, we selected five species of the genus\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    , commonly found in fermented foods, and acknowledged them as safe, edible, and effective in preventing or treating certain diseases, to evaluate their effects on alcoholic liver disease (ALD). By comparing the liver damage indices in each group, we found that the type strain of\n                    <jats:italic>Lactobacillus helveticus<\/jats:italic>\n                    (LH, ATCC 15009) had the most marked alleviating effect on ALD\u2010induced liver injury. Furthermore, experiments combining microbiomics and metabolomics were conducted to explore the mechanisms underlying the hepatoprotective effects of LH. Finally, we discovered that LH mitigated ethanol\u2010induced liver steatosis and inflammation in ALD mice by altering the structure and function of the gut microbiome, increasing intestinal levels of short\u2010chain fatty acids (SCFAs), and enhancing gut barrier integrity. These findings suggest a potential strategy for the clinical management of patients with ALD.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70016","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T09:09:26Z","timestamp":1729501766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Lactobacillus helveticus attenuates alcoholic liver injury via regulation of gut microecology in mice"],"prefix":"10.1111","volume":"17","author":[{"given":"Jiawen","family":"Lv","sequence":"first","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, National Medical Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"College of 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