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Given the asymptomatic nature of many STIs, diagnostic testing is critical for determining the appropriate treatment, enabling effective tracing and reducing the risk of further transmission. Nucleic acid amplification tests (NAATs) are the most sensitive and the most widely used in well\u2010resourced settings. The majority of available NAATs are based on polymerase chain reaction (PCR), which requires highly trained personnel and costly equipment, making it impractical for resource\u2010limited settings. Loop\u2010mediated isothermal amplification (LAMP) has emerged as a simple, rapid, sensitive and low\u2010cost alternative for pathogen detection, particularly well\u2010suited for point\u2010of\u2010care tests (POCT). In this review, we evaluate LAMP assays reported in the literature for the detection of pathogens linked to the high incidence STIs prioritised by the World Health Organization (WHO) for POCT in 2023. These include\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Chlamydia trachomatis<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:italic>Trichomonas vaginalis<\/jats:italic>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>T. pallidum<\/jats:italic>\n                    <\/jats:styled-content>\n                    subspecies\n                    <jats:italic>pallidum<\/jats:italic>\n                    , as well as other common STIs such as herpes simplex virus, hepatitis B virus and human immunodeficiency virus (HIV). For each LAMP assay, we identified and summarised the key elements such as the type and number of tested clinical specimens, chosen target gene, detection system, reference test and clinical outcomes. We highlight the advantages and limitations of these assays and discuss the gaps that should be addressed to improve their applicability for POCT.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70153","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T12:20:13Z","timestamp":1746188413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Loop\u2010Mediated Isothermal Amplification (\n                    <scp>LAMP<\/scp>\n                    ) for the Diagnosis of Sexually Transmitted Infections: A Review"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4563-830X","authenticated-orcid":false,"given":"Yasaman","family":"Ahmadi","sequence":"first","affiliation":[{"name":"Department of Engineering Science University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yejiong","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Engineering Science University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanfeng","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Engineering Science University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1302-6528","authenticated-orcid":false,"given":"Wei E.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Engineering Science University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique I.","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Microbiology Oxford University Hospitals NHS Foundation Trust  Oxford UK"},{"name":"Nuffield Division of Clinical Laboratory Science, Radcliffe Department of Medicine University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"25","article-title":"Loop\u2010Mediated Isothermal Amplification (LAMP) Assay for the Rapid Detection of the Sexually\u2010Transmitted Parasite, Trichomonas vaginalis","volume":"62","author":"Adao D. 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