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Siderophores exhibit bioactivities ranging from chelation for iron reduction in hemochromatosis sufferers to antimicrobial activity either in their own right or when coupled to known antibiotics for targeted delivery or for molecular imaging. Thus, marine environments are a sought\u2010after resource for novel siderophores that could have pharmaceutical or industrial application. The fimsbactins A\u2010F (\n                    <jats:bold>1\u20136<\/jats:bold>\n                    ) are mixed catechol\u2010hydroxamate siderophores that have only been reported to be produced by\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    species with the fimsbactin biosynthetic gene clusters (BGCs) widespread among species within this genus. Here, we identified a putative fimsbactin BGC from an uncharacterized marine isolate,\n                    <jats:italic>Marinomonas<\/jats:italic>\n                    sp. PE14\u201040. Not only was the gene synteny not conserved when comparing the pathway from\n                    <jats:italic>Marinomonas<\/jats:italic>\n                    sp. PE14\u201040 to the fimsbactin BGC from\n                    <jats:italic>Acinetobacter<\/jats:italic>\n                    sp., but five of the core biosynthetic genes found in the canonical fimsbactin BGC are located elsewhere on the genome and do not form part of the core cluster in\n                    <jats:italic>Marinomonas<\/jats:italic>\n                    sp. PE14\u201040, with four of these,\n                    <jats:italic>fbsBCDL,<\/jats:italic>\n                    colocalized. Through ESI\u2010MS\/MS analysis of extracts from\n                    <jats:italic>Marinomonas<\/jats:italic>\n                    sp. PE14\u201040, the known fimsbactin analogues\n                    <jats:bold>1<\/jats:bold>\n                    and\n                    <jats:bold>6<\/jats:bold>\n                    were identified, as well as two new fimsbactin analogues,\n                    <jats:bold>7<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    , containing a previously unreported L\u2010lysine\u2010derived hydroxamate moiety,\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                    <\/jats:sub>\n                    \u2010acetyl\u2010\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                    <\/jats:sub>\n                    \u2010hydroxycadaverine. Feeding experiments using stable isotope\u2010label L\u2010lysine provided further evidence of the\n                    <jats:italic>N<\/jats:italic>\n                    <jats:sub>\n                      <jats:italic>1<\/jats:italic>\n                    <\/jats:sub>\n                    \u2010acetyl\u2010\n                    <jats:italic>N<\/jats:italic>\n                    <jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                    <\/jats:italic>\n                    \u2010hydroxycadaverine moiety in\n                    <jats:bold>7<\/jats:bold>\n                    and\n                    <jats:bold>8<\/jats:bold>\n                    . The study demonstrates functional conservation in seemingly disparate biosynthetic pathways and enzyme promiscuity's role in producing structurally diverse compounds.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70155","type":"journal-article","created":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T02:01:45Z","timestamp":1746496905000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fimsbactin Siderophores From a South African Marine Sponge Symbiont,\n                    <i>Marinomonas<\/i>\n                    sp.\n                    <scp>PE<\/scp>\n                    14\u201040"],"prefix":"10.1111","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-850X","authenticated-orcid":false,"given":"Nompumelelo Philile Praiseworth","family":"Ikegwuoha","sequence":"first","affiliation":[{"name":"Department of Biotechnology Institute for Microbial Biotechnology and Metagenomics (IMBM), 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