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Among the major human pathogens is the Gram\u2010negative bacterium\n                    <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    , which is particularly due to its wide range of drug resistance mechanisms. Aminoglycosides, which have long been used in treating pseudomonal infections, are increasingly undermined by resistance. This opinion article discusses the use and challenges of aminoglycosides against\n                    <jats:italic>P. aeruginosa<\/jats:italic>\n                    and highlights recent strategies that enhance aminoglycoside efficacy. These include combinational therapies, metabolic stimulants\/adjuvants, silver, and more recently developed derivatives such as AGXX, many of which have been reported to potentiate the cytotoxic effects of aminoglycosides and re\u2010sensitise aminoglycoside\u2010resistant strains. While these findings pave the way for future therapies, the clinical relevance of many in\u00a0vitro studies remains to be investigated.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70174","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:54:37Z","timestamp":1748652877000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Unlocking Enhanced Efficacy of Aminoglycoside Antibiotics Against\n                    <i>Pseudomonas aeruginosa<\/i>"],"prefix":"10.1111","volume":"18","author":[{"given":"Patrick Ofori","family":"Tawiah","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Microbiology Illinois State University  Normal Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadia","family":"Sultana","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Microbiology Illinois State University  Normal Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8597-7416","authenticated-orcid":false,"given":"Jan\u2010Ulrik","family":"Dahl","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Microbiology Illinois State University  Normal Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2023.106887"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2624"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.36.9.1951"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics7030079"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084220"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(87)90349-4"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00976-22"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01293-19"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.824042"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01835-17"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01050-12"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.403-434.2006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1007697"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.16.6164"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002184"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.02198-14"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00190-23"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.04519-22"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1064095"},{"key":"e_1_2_11_21_1","first-page":"E2100","article-title":"Antibiotics Induce Redox\u2010Related Physiological Alterations as Part of Their Lethality","volume":"111","author":"Dwyer D. 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