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Whole\u2010genome sequencing and functional prediction revealed that it is rich in carbohydrate metabolism and lipid metabolism genes, as well as short\u2010chain fatty acid synthesis genes. Preliminary experiments on high\u2010sugar and high\u2010fat zebrafish showed that LPP has the potential to improve glucose and lipid metabolism. Subsequently, in a high\u2010fat\/high\u2010fructose obese rat experiment, a 7\u2010week intervention with LPP was conducted. Without altering energy intake, the high\u2010dose LPP (LPPH) significantly reduced body weight and fat mass (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), improved insulin sensitivity (reduced HOMA\u2010IR and fasting blood glucose,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and normalised lipid profiles, thereby enhancing glucose homeostasis. This intervention reversed gut microbial dysbiosis by enriching beneficial bacteria (\n                    <jats:italic>Akkermansia<\/jats:italic>\n                    and\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    ) and suppressing pathogens (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Klebsiella pneumoniae<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:italic>Ruminococcus<\/jats:italic>\n                    ), while also increasing short\u2010chain fatty acids (butyrate\/acetate) associated with improved metabolism. Transcriptome analysis revealed that LPPH remodelled adipose tissue through the PPAR signalling pathway (downregulating\n                    <jats:italic>Pparg<\/jats:italic>\n                    and upregulating\n                    <jats:italic>Cpt1a<\/jats:italic>\n                    ) and activated the hepatic PI3K\u2010Akt signalling pathway to enhance insulin sensitivity. These results suggest that LPPH alleviates metabolic disorders by synergistically regulating the gut microbiota\u2010fat\u2010liver axis (independent of appetite suppression), making it a promising probiotic therapy for the treatment of obesity\u2010related metabolic disorders.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70227","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T18:41:17Z","timestamp":1761763277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["<i>Lactiplantibacillus plantarum<\/i>\n                    Attenuates Diet\u2010Induced Obesity and Insulin Resistance Through Gut Microbiota\u2010Driven\n                    <i>PPAR\/PI3K<\/i>\n                    \u2010Axis Modulation"],"prefix":"10.1111","volume":"18","author":[{"given":"Yecheng","family":"Gao","sequence":"first","affiliation":[{"name":"Inner Mongolia Key Laboratory of Dairy Biotechnology and Engineering Inner Mongolia Agricultural University  Hohhot Inner Mongolia China"},{"name":"Key Laboratory of Dairy Products Processing, Ministry of Agriculture and Rural Affairs Inner Mongolia Agricultural University  Hohhot Inner Mongolia China"},{"name":"Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education Inner Mongolia Agricultural University  Hohhot Inner Mongolia China"},{"name":"Perfect (Guangdong) Co., Ltd.  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