{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T19:17:19Z","timestamp":1789067839241,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173903"],"award-info":[{"award-number":["82173903"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81903686"],"award-info":[{"award-number":["81903686"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Olanzapine is associated with a high risk of hepatic steatosis as a commonly used atypical antipsychotic. In this study, we observed differential susceptibility to olanzapine\u2010induced fatty liver disease in both rats and patients. Notably, patients with olanzapine\u2010induced liver damage exhibited an altered gut microbiota composition, with\n \n Akkermansia muciniphila<\/jats:italic>\n <\/jats:styled-content>\n showing the most pronounced alteration. To explore its therapeutic potential, we administered\n \n A. muciniphila<\/jats:italic>\n <\/jats:styled-content>\n to olanzapine\u2010treated rats, which significantly reduced hepatic lipid accumulation and liver injury. Gut microbiome analysis revealed significant alterations in microbial diversity and composition following\n \n A. muciniphila<\/jats:italic>\n <\/jats:styled-content>\n treatment. Transcriptomic analysis further identified differentially expressed genes in the liver, highlighting the involvement of\n IGFBP2<\/jats:italic>\n and\n APOA1<\/jats:italic>\n in the protective effects of\n \n A. muciniphila<\/jats:italic>\n <\/jats:styled-content>\n . Functional validation demonstrated that overexpression of\n IGFBP2<\/jats:italic>\n and\n APOA1<\/jats:italic>\n alleviated olanzapine\u2010induced hepatic steatosis in both cellular and animal models. These findings suggest that\n \n A. muciniphila<\/jats:italic>\n <\/jats:styled-content>\n exerts hepatoprotective effects via the gut microbiota\u2010IGFBP2\/APOA1\u2010liver axis, offering a potential microbiota\u2010targeted strategy to mitigate olanzapine\u2010induced metabolic dysfunction.\n <\/jats:p>","DOI":"10.1111\/1751-7915.70281","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T06:21:33Z","timestamp":1765434093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Akkermansia muciniphila<\/i>\n Alleviates Olanzapine\u2010Induced Hepatic Steatosis via the Gut Microbiota\u2010\n IGFBP2<\/scp>\n \/\n APOA1<\/scp>\n \u2010Liver Axis"],"prefix":"10.1111","volume":"18","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 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