{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:37:54Z","timestamp":1790876274475,"version":"4.1.0"},"reference-count":169,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32202380"],"award-info":[{"award-number":["32202380"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Type 2 diabetes mellitus (T2DM) poses a significant threat to public health and is associated with the gut microbiota. Gut microbiota modulators, including probiotics, prebiotics, and synbiotics, together with faecal microbiota transplantation (FMT), can restore the gut microbiota in patients and are recognised as powerful modulators of this ecosystem. Consequently, gut microbiota modulators are promising in the prevention and treatment of T2DM. The roles and mechanisms by which these therapeutic approaches target the gut microbiota in patients with T2DM warrant further investigation and elucidation. Key potential mechanisms associated with gut microbiota regulation include the modulation of gut microbiota composition alteration of gut microbiota metabolites, enhancement of intestinal barrier function, and suppression of inflammation. This study provides a comprehensive review of the relationship between the gut microbiota and T2DM, presents promising research findings and controversial issues, emphasises the potential roles and mechanisms of the gut microbiota in T2DM, and investigates the factors influencing the therapeutic efficacy of FMT. This review serves as a valuable reference for future studies on FMT.<\/jats:p>","DOI":"10.1111\/1751-7915.70283","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T12:54:37Z","timestamp":1765803277000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Targeted Therapy for Gut Microbiota: Candidates for a Novel Strategy to Ameliorate Type 2 Diabetes Mellitus"],"prefix":"10.1111","volume":"18","author":[{"given":"Jiangyan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaofei","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Li","sequence":"additional","affiliation":[{"name":"School of Foreign Languages of Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1266-8426","authenticated-orcid":false,"given":"Hao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6683-162X","authenticated-orcid":false,"given":"Shuo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-8513","authenticated-orcid":false,"given":"Xingxiang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota\u2010Targeted Therapies of Guangdong Province The First Affiliated Hospital of Guangdong Pharmaceutical University  Guangzhou China"},{"name":"Guangdong Provincial Key Laboratory for Research and Evaluation of Pharmaceutical Preparations  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2019.01.011"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00143"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13030713"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1462-2920.13181"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.006"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-021-09744-0"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-019-1180-z"},{"issue":"2","key":"e_1_2_12_9_1","first-page":"163","article-title":"Comparative Study of Effect of Akkermansia Muciniphila and Its Extracellular Vesicles on Toll\u2010Like Receptors and Tight Junction","volume":"12","author":"Ashrafian F.","year":"2019","journal-title":"Gastroenterology and Hepatology From Bed to Bench"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60207-X"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis812"},{"key":"e_1_2_12_12_1","article-title":"The Supplementation of the Multi\u2010Strain Probiotics WHHPRO Alleviates High\u2010Fat Diet\u2010Induced Metabolic Symptoms in Rats via Gut\u2010Liver Axis","volume":"10","author":"Cailing C.","year":"2023","journal-title":"Frontiers in Nutrition"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.54"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3354"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11061225"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2023.1069954"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c02429"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1128\/msystems.01300-22"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2018.04.018"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0FO02748K"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2020.1733483"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0556-9"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2003.10.013"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8FO00081F"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-29005-0"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.12.022"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2017.1293224"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910437"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.02.032"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2015.12.010"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2022.159234"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1864"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2010.00797.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-021-00837-6"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.820367"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-019-00809-2"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ085"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40200-017-0304-8"},{"issue":"5","key":"e_1_2_12_39_1","first-page":"854","article-title":"Fecal Enema as an Adjunct in the Treatment of Pseudomembranous Enterocolitis","volume":"44","author":"Eiseman B.","year":"1958","journal-title":"Surgery"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219451110"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365548609032337"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4611"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12721"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123720"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2019.03.055"},{"key":"e_1_2_12_46_1","volume-title":"Handbook of Prescriptions for Emergencies (Volume 2)","author":"Ge H.","year":"2000"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2011.00149"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.12267"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116385"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00202"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117546"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0447"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu16020269"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2021.1954667"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2024.150831"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11112791"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods14010023"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-02135-w"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32015-7"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/hsr2.2004"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35014-1"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2019-001028"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-020-00450-2"},{"key":"e_1_2_12_64_1","volume-title":"The Function and of the Key Bacteria Isolated From Kazaks and Uighurs in Xinjiang with Type 2 Diabetes in Mice","author":"Hu S.","year":"2016"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14010166"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.17-44"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1323599111"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020558"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12198"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aay6218"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.4419"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.09.008"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-021-3334-5"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516003627"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009085"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22073566"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO00698C"},{"issue":"1","key":"e_1_2_12_78_1","first-page":"83","article-title":"Perceptions of Fecal Microbiota Transplantation for Clostridium difficile Infection: Factors That Predict Acceptance","volume":"30","author":"Leslie P.","year":"2017","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis319"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093211"},{"key":"e_1_2_12_81_1","volume-title":"Compendium of Materia Medica (Volume 52)","author":"Li S.","year":"2011"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103756"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.14260"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-024-13041-5"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.136389"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1237934"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2019.11.001"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.4314"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.56598"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.171"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117627"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370217708188"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03067-7"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327365"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201900922"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2019.05.016"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-020-00917-7"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.07.034"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.13044"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081800"},{"key":"e_1_2_12_101_1","doi-asserted-by":"crossref","first-page":"4025","DOI":"10.2147\/DMSO.S421134","article-title":"Electroacupuncture Improves Insulin Resistance in Type 2 Diabetes Mice by Regulating Intestinal Flora and Bile Acid","volume":"16","author":"Pan T.","year":"2023","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.928785"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24119533"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18646"},{"issue":"6","key":"e_1_2_12_105_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0251646","article-title":"Multi\u2010Strain Probiotic Supplement Attenuates Streptozotocin\u2010Induced Type\u20102 Diabetes by Reducing Inflammation and \u03b2\u2010Cell Death in Rats","volume":"16","author":"Pei Shan H.","year":"2021","journal-title":"PLoS One"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.2337\/db11-0030"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00998-9"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.11.081"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1097\/MOG.0000000000000057"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11102393"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1797-8"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18507"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.06.050"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00041.2015"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc13-2817"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90753-5"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micpath.2017.08.038"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000000954"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1242-9"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.4"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06466-x"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800100-4.00003-9"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2009.08.001"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2014-306928"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-020-10689-7"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11552"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms8040483"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.031"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-022-01155-8"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-018-0800-3"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1128\/Spectrum.00042-21"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155575"},{"key":"e_1_2_12_133_1","article-title":"Gut Microbiome Analysis of Type 2 Diabetic Patients From the Chinese Minority Ethnic Groups the Uygurs and Kazaks","volume":"12","author":"Wang Y.","year":"2017","journal-title":"PLoS One"},{"key":"e_1_2_12_134_1","first-page":"1","article-title":"Faecal Microbiota Transplantation Is Better Than Probiotics for Tissue Regeneration of Type 2 Diabetes Mellitus Injuries in Mice","volume":"130","author":"Wang Y.","year":"2022","journal-title":"Archives of Physiology and Biochemistry"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2019.00455"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-62752-4"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1114424"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.111036"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.985636"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1044957"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2021.110550"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.1c02925"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00284-010-9582-9"},{"issue":"11","key":"e_1_2_12_144_1","article-title":"Fecal Bacterial Community and Metagenome Function in Asians With Type 2 Diabetes, According to Enterotypes","volume":"10","author":"Wu X.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.1089991"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2021.01275"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2023.10794"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-022-13759-9"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.06.010"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2019.86611"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153268"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-024-03131-z"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-021-00880-5"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2004.tb00887.x"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.156151"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081515"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03483-1"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO04387K"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.251"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i41.7213"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0330-9"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-019-00684-8"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-023-02880-0"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1420103"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e30310"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2024.04.009"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04570-0"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy182"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0927"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.732204"}],"container-title":["Microbial Biotechnology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1751-7915.70283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T05:53:02Z","timestamp":1766987582000},"score":1,"resource":{"primary":{"URL":"https:\/\/sfamjournals.onlinelibrary.wiley.com\/doi\/10.1111\/1751-7915.70283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":169,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/1751-7915.70283"],"URL":"https:\/\/doi.org\/10.1111\/1751-7915.70283","archive":["Portico"],"relation":{},"ISSN":["1751-7915","1751-7915"],"issn-type":[{"value":"1751-7915","type":"print"},{"value":"1751-7915","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-07-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70283"}}