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Although\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lactobacillus salivarius<\/jats:italic>\n                    <\/jats:styled-content>\n                    Li01 (Li01) is a well\u2010characterised probiotic strain, its specific role in AP via the \u2018gut\u2010pancreas axis\u2019 remains unclear. Li01 pretreatment via oral gavage was assessed in an L\u2010arginine\u2010induced AP mouse model. The gut microbiota composition and abundance were analysed via 16S rRNA sequencing, complemented by untargeted faecal metabolomics and pancreatic transcriptomics analyses. Li01 pretreatment significantly alleviated histopathological damage to the pancreas and reduced serum amylase activity in AP model mice. Pancreatic transcriptomic analysis revealed that Li01 modulated the expression of 89 differentially expressed genes (DEGs), thereby impacting key immune\u2010related signalling pathways, including the TNF\u2010\u03b1 signalling pathway. Furthermore, Li01 mitigated gut microbiota dysbiosis in AP mice, notably by increasing the relative abundance of bacteria such as\n                    <jats:italic>Paramuribaculum<\/jats:italic>\n                    . Faecal metabolomics analysis indicated that Li01 intervention significantly increased the levels of metabolites involved in steroid hormone biosynthesis, including 17\u03b1\u2010estradiol. Li01 may alleviate AP by modulating the gut microbiota composition, increasing the relative abundance of bacteria such as\n                    <jats:italic>Paramuribaculum<\/jats:italic>\n                    , and regulating faecal metabolite profiles, particularly those involved in the steroid hormone biosynthesis pathway. These modulations, in turn, appear to influence pancreatic inflammation\u2010related signalling pathways, including the TNF signalling pathway.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70300","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T15:45:21Z","timestamp":1768578321000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Multi\u2010Omics Analysis Reveals the Potential Preventive Mechanism of\n                    <scp>\n                      <i>Lactobacillus salivarius<\/i>\n                    <\/scp>\n                    Li01 Against L\u2010Arginine\u2010Induced Acute Pancreatitis in Mice"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-4263-9326","authenticated-orcid":false,"given":"Jiamin","family":"Duan","sequence":"first","affiliation":[{"name":"College of Life Sciences and Medicine Zhejiang Sci\u2010Tech University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Lou","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyu","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou 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