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To overcome high discovery rates from conventional sources, this study utilised a hazard\u2010to\u2010solution biotechnology paradigm, successfully transforming the sanitary pest\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Periplaneta americana<\/jats:italic>\n                    <\/jats:styled-content>\n                    into a sustainable bioresource for novel antifungal agents. Herein, an integrated multi\u2010omics framework was established to systematically characterise the biosynthetic potential of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Streptomyces sampsonii<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain WA1\u201019, a symbiont of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. americana<\/jats:italic>\n                    <\/jats:styled-content>\n                    exhibiting potent activity against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    . Whole\u2010genome sequencing and anti\u2010SMASH analysis revealed eight biosynthetic gene clusters of the strain, including one with 100% similarity to candicidin, providing a genomic rationale for its biocontrol capability. Subsequently, untargeted metabolomics coupled with GNPS analysis was employed to connect the genomic potential to the expressed chemistry of the strain, and several bioactive metabolites were identified such as surugamides, daizein and so on. Network pharmacology analysis predicted that the inhibitory effects of these metabolites against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    might be associated with the core virulence pathways of the pathogen, particularly MAPK and PI3K\u2010Akt signalling cascades. In summary, this study presents\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. sampsonii<\/jats:italic>\n                    <\/jats:styled-content>\n                    strain WA1\u201019 as a promising biocontrol candidate and validates a multi\u2010omics workflow that offers a powerful strategy for antimicrobial discovery from underexplored insect niches.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70333","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:36:04Z","timestamp":1775882164000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Multi\u2010Omics Analysis of a\n                    <scp>\n                      <i>Periplaneta americana<\/i>\n                    <\/scp>\n                    Symbiont\n                    <scp>\n                      <i>Streptomyces sampsonii<\/i>\n            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