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These wall\u2010deficient morphotypes are increasingly recognised as functional bacterial states with emerging biotechnological relevance, yet the environmental signals that trigger their formation remain poorly defined. Here, we show that the flavonoids daidzein and genistein act as defined chemical inducers of wall\u2010deficient cell formation in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Streptomyces coelicolor<\/jats:italic>\n                    <\/jats:styled-content>\n                    under hyperosmotic stress (0.64\u2009M sucrose). Although the wild\u2010type strain fails to produce wall\u2010deficient cells in standard laboratory media under hyperosmotic conditions, robust formation of non\u2010dividing stress\u2010induced cells (S\u2010cells), along with a small proportion of dividing L\u2010forms, is observed in soya flour\u2013mannitol medium (SFM) supplemented with high sucrose concentrations. We show that wall\u2010deficient cell formation can be induced by the addition of daidzein and genistein, the most abundant soybean flavonoids, to flavonoid\u2010free media containing high sucrose concentrations, at levels comparable to those found in SFM. These results identify flavonoids as defined chemical inducers of wall\u2010deficient morphogenesis in\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    . More broadly, our findings suggest a link between plant secondary metabolites and bacterial morphological plasticity, with potential implications for plant\u2013microbe interactions and microbial biotechnology.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70366","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T11:40:26Z","timestamp":1780659626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Flavonoids Daidzein and Genistein Induce Wall\u2010Deficient Cell Formation in\n                    <i>Streptomyces coelicolor<\/i>\n                    Under Hyperosmotic Stress"],"prefix":"10.1111","volume":"19","author":[{"given":"Paula","family":"Vald\u00e9s\u2010Chiara","sequence":"first","affiliation":[{"name":"Department of Functional Biology, Microbiology Area, IUOPA and ISPA, Faculty of Medicine Universidad de Oviedo  Oviedo 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