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Although chromosomal integration of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20105<\/jats:sub>\n                    has been described in other\n                    <jats:italic>Enterobacterales<\/jats:italic>\n                    and\n                    <jats:italic>Salmonella<\/jats:italic>\n                    serovars, this is the first such report in this high\u2010risk clone. This study characterises the genomic and epidemiological background of this strain. The isolate (1111\u201090), obtained from a paediatric patient, was subjected to antimicrobial susceptibility testing, whole\u2010genome sequencing and comparative genomic analysis against 674 complete\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20105<\/jats:sub>\n                    \u2010positive plasmids retrieved from the PlasmidScope database. The isolate exhibited a multidrug\u2010resistant phenotype, including carbapenem resistance, while retaining susceptibility to tigecycline and aztreonam. It harboured 13 resistance genes distributed across the chromosome and two plasmids. The ~11\u2009kb chromosomally integrated\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20105<\/jats:sub>\n                    segment is flanked by directly oriented IS\n                    <jats:italic>26<\/jats:italic>\n                    elements, forming an IS\n                    <jats:italic>26<\/jats:italic>\n                    \u2010bounded composite transposon with no canonical target\u2010site duplication at its boundaries. Phylogenetic analysis suggested that this chromosomal segment likely originated from IncX3 or IncI1 plasmid lineages prevalent in China. Comparative genetic analysis highlighted the significant role of mobile genetic elements (IS\n                    <jats:italic>26<\/jats:italic>\n                    , IS\n                    <jats:italic>5<\/jats:italic>\n                    and IS\n                    <jats:italic>3000<\/jats:italic>\n                    ) in the spread of\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20105<\/jats:sub>\n                    within\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>S. typhimurium<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The chromosomal integration of an IS\n                    <jats:italic>26<\/jats:italic>\n                    \u2010bounded\n                    <jats:italic>bla<\/jats:italic>\n                    <jats:sub>NDM\u20105<\/jats:sub>\n                    module in\n                    <jats:italic>S<\/jats:italic>\n                    . 1,4,[5],12:i:\u2010 ST34 suggests the emergence of a stable, high\u2010risk carbapenem\u2010resistant clone, underscoring the need for genomic surveillance to track IS\n                    <jats:italic>26<\/jats:italic>\n                    \u2010mediated chromosomal integration events.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70413","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:35:11Z","timestamp":1783920911000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification and Genomic Analysis of the First\n                    <scp>\n                      <i>Salmonella typhimurium<\/i>\n                    <\/scp>\n                    Monophasic Variant 1,4,[5],12:i:\u2010 Isolate Harbouring a Chromosomally Integrated\n                    <scp>\n                      <i>bla<\/i>\n                      <sub>NDM\u20105<\/sub>\n                    <\/scp>"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-1849","authenticated-orcid":false,"given":"Shihan","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory, Fifth Affiliated Hospital Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8603-8850","authenticated-orcid":false,"given":"Weilong","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory, Fifth Affiliated Hospital Southern Medical University  Guangzhou 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