{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:38:46Z","timestamp":1793122726467,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370809"],"award-info":[{"award-number":["82370809"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Infancy represents a critical period for growth and development, during which the gut microbiota and its metabolites play essential roles in nutrient absorption and maintaining health. Therefore, it is of great significance to evaluate the safety and gut microbiota\u2010modulating effects of specific probiotics in healthy infants. This study aimed to investigate the effect of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Bifidobacterium animalis<\/jats:italic>\n                    <\/jats:styled-content>\n                    subsp.\n                    <jats:italic>lactis<\/jats:italic>\n                    CP\u20109 strain (CP\u20109) on healthy infants aged 6 to 36\u2009months and its relationship with growth patterns and multidimensional indicators. In this randomized, double\u2010blind, placebo\u2010controlled trial, healthy infants were randomly assigned to receive CP\u20109 or placebo for 3\u2009months. Safety, growth parameters, complete blood counts (CBC), immunological markers and faecal microbiota were assessed before and after the intervention. All infants exhibited age\u2010appropriate growth in height and head circumference during the study. The CP\u20109 strain significantly increased gut\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    abundance and regulated the microbiota\u2010mediated polyunsaturated fatty acids biosynthesis pathway. Haematological and systemic inflammatory markers remained within normal ranges and no treatment\u2010related adverse changes were detected during the 3\u2010month intervention period. Moreover, CP\u20109 improved stool characteristics and gastrointestinal tolerability, with no increase in the incidence of respiratory allergies, skin allergies, respiratory infections, or fever, which further confirmed its safety. These findings suggested that CP\u20109 supplementation resulted in significant enrichment of\n                    <jats:italic>Bifidobacterium<\/jats:italic>\n                    , a beneficial gut bacterium and had no detectable adverse effects on the measured physiological parameters. Consequently, the intervention raised no detectable safety concerns in healthy infants under the conditions of this study. Given this, CP\u20109 is a probiotic that does not show any obvious short\u2010term safety signals for infants aged 6 to 36\u2009months.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70421","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T07:46:15Z","timestamp":1785397575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of\n                    <i>Bifidobacterium animalis<\/i>\n                    Subsp.\n                    <i>Lactis<\/i>\n                    <scp>CP<\/scp>\n                    \u20109 on Gut Microbiota and Immune Functions in Healthy Infants"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9825-8706","authenticated-orcid":false,"given":"Liujing","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition Affiliated Hospital of Jiangnan University  Wuxi Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4011-8463","authenticated-orcid":false,"given":"Xueke","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition The Second Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-1448-2828","authenticated-orcid":false,"given":"Keming","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3621-2496","authenticated-orcid":false,"given":"Xiaoshuang","family":"Xu","sequence":"additional","affiliation":[{"name":"Central Laboratory The Second Affiliated Hospital of Nanjing Medical University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-9044-8920","authenticated-orcid":false,"given":"Xinmei","family":"Guo","sequence":"additional","affiliation":[{"name":"Research and Development Department Jinqiao Biotech co., Ltd.  Huaian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2428-2502","authenticated-orcid":false,"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Research and Development Department Jinqiao Biotech co., Ltd.  Huaian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7038-9571","authenticated-orcid":false,"given":"Xiaoling","family":"Zeng","sequence":"additional","affiliation":[{"name":"Research and Development Department Jinqiao Biotech co., Ltd.  Huaian Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingguang","family":"Xie","sequence":"additional","affiliation":[{"name":"Jining No. 1 People's Hospital  Jining Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4204-7710","authenticated-orcid":false,"given":"Liwei","family":"Nie","sequence":"additional","affiliation":[{"name":"Women and Children's Health Care Hospital of Linyi  Linyi Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0255-6916","authenticated-orcid":false,"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Panjin Liaohe Gemstone Flower Hospital  Panjin Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7469-0065","authenticated-orcid":false,"given":"Xuelu","family":"Dai","sequence":"additional","affiliation":[{"name":"Department 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