{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:38:22Z","timestamp":1793122702023,"version":"4.5.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Emerging research has revealed a diverse microbiota in the high myopia (HM) conjunctival sac, highlighting the therapeutic potential of modulating this community to influence disease outcomes. However, current research on targeted modulation of this microbiota for myopia intervention lacks in\u2010depth investigation and definitive conclusions regarding its efficacy and underlying mechanisms. In this study, high\u2010throughput sequencing and culturomics were first used to screen the conjunctival sac microbiota of healthy people, identifying\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Lactobacillus mucosae<\/jats:italic>\n                    <\/jats:styled-content>\n                    MM\u20101 as a potential probiotic for myopia control. Then, animal studies further confirmed that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. mucosae<\/jats:italic>\n                    <\/jats:styled-content>\n                    MM\u20101 significantly attenuated lens\u2010induced myopia, improved COL1A1 expression and scleral integrity and elevated\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    abundance. Furthermore, untargeted metabolomics analysis suggested that indole\u20103\u2010lactic acid (ILA) may be a key substance for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. mucosae<\/jats:italic>\n                    <\/jats:styled-content>\n                    MM\u20101 to exert its effects for myopia control. Mechanistically, pharmacological ILA supplementation supports the involvement of AHR in TGF\u2010\u03b2\/Smad pathway inhibition, accompanied by altered COL1A1 and \u03b1\u2010SMA expression and attenuation of lens\u2010induced myopia in mice. Therefore, these findings suggest that\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. mucosae<\/jats:italic>\n                    <\/jats:styled-content>\n                    MM\u20101 may attenuate lens\u2010induced myopia in mice, at least in part, through ILA\u2010mediated regulation of the TGF\u2010\u03b2\/Smad pathway, and offer a theoretical foundation for future therapeutic strategies based on conjunctival sac microbiome manipulation.\n                  <\/jats:p>","DOI":"10.1111\/1751-7915.70426","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T09:07:08Z","timestamp":1786093628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Conjunctival Sac\u2010Derived\n                    <i>Lactobacillus mucosae<\/i>\n                    MM\u20101 Metabolite Indole\u20103\u2010Lactic Acid Attenuates Lens\u2010Induced Myopia in Mice via AHR Activation and TGF\u2010\u03b2\/Smad Inhibition"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5027-2886","authenticated-orcid":false,"given":"Yanqing","family":"Li","sequence":"first","affiliation":[{"name":"Department of Ophthalmic Center, The Second Affiliated Hospital, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province China"},{"name":"School of Pharmacy, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province China"},{"name":"Jiangxi Province Key Laboratory of Bioengineering Drugs, Institute of Translational Medicine, Jiangxi Medical College Nanchang University  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3455-4794","authenticated-orcid":false,"given":"Qiuyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Queen Mary School, Jiangxi Medical College Nanchang University  Nanchang Jiangxi Province 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