{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:03:10Z","timestamp":1790593390118,"version":"4.1.0"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T00:00:00Z","timestamp":1788652800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100019188","name":"HORIZON EUROPE Excellent Science","doi-asserted-by":"publisher","award":["CL6\u20102021\u2010UE 101060625"],"award-info":[{"award-number":["CL6\u20102021\u2010UE 101060625"]}],"id":[{"id":"10.13039\/100019188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["enviromicro-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Microbial Biotechnology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The deliberate release of genetically engineered microorganisms for environmental applications has remained largely blocked since the early days of recombinant DNA technology, when limited ecological knowledge, lack of success stories and public apprehension shaped a culture of caution and restrictive regulation. Despite profound advances in microbial ecology, synthetic biology and genetic design, current frameworks still rely on outdated assumptions and legacy regulations that equate engineered microbes with inherent danger and demand unrealistic forms of absolute containment. This review examines how laboratory\u2010trained microorganisms exist on a continuum with naturally evolved life, and that their risks are neither categorically different nor greater. Rather than pursuing unachievable containment, governance should shift towards traceability, stewardship and long\u2010term monitoring through genomic barcodes, digital twins and transparent oversight. The vision moves from domination and control to care and partnership recognizing engineered microbes as live amendments capable of restoring degraded ecosystems. Achieving this transformation requires new terminology, phased field\u2010trial frameworks, improved scaling methods, and the integration of epistemological perspectives that emphasize reciprocity and coexistence with nature. Reframing biotechnology in this way could finally unlock the capacity of engineered microorganisms to contribute responsibly and effectively to planetary repair in an era of escalating environmental crises.<\/jats:p>","DOI":"10.1111\/1751-7915.70441","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T06:22:21Z","timestamp":1788762141000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Environmental Release of Genetically Intervened Microorganisms: Towards a New Narrative"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-2731","authenticated-orcid":false,"given":"Victor","family":"de Lorenzo","sequence":"first","affiliation":[{"name":"Systems Biology Department National Center of Biotechnology CSIC  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,6]]},"reference":[{"key":"e_1_2_21_2_1","doi-asserted-by":"publisher","DOI":"10.34133\/2022\/9850305"},{"key":"e_1_2_21_3_1","first-page":"419","article-title":"Using Regulation to Change the Market for Innovation","volume":"9","author":"Ashford N.","year":"2002","journal-title":"Harvard Environmental Law Review"},{"key":"e_1_2_21_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-57935-y"},{"key":"e_1_2_21_5_1","doi-asserted-by":"publisher","DOI":"10.4159\/9780674020672"},{"key":"e_1_2_21_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2024.02.002"},{"key":"e_1_2_21_7_1","doi-asserted-by":"publisher","DOI":"10.38126\/JSPG260201"},{"key":"e_1_2_21_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2025.102685"},{"key":"e_1_2_21_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1979"},{"key":"e_1_2_21_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0278471"},{"key":"e_1_2_21_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-024-01918-0"},{"key":"e_1_2_21_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2026.07.001"},{"key":"e_1_2_21_13_1","first-page":"188","article-title":"Construction of Biologically Functional Bacterial Plasmids In\u00a0Vitro. 1973","volume":"24","author":"Cohen S. 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