{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:22:40Z","timestamp":1773922960444,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of the present study was to determine whether the administration of D<\/jats:styled-content>iamel, marketed as a food supplement by C<\/jats:styled-content>atalysis L<\/jats:styled-content>aboratories (M<\/jats:styled-content>adrid, S<\/jats:styled-content>pain) could improve any of the components of metabolic syndrome (MS<\/jats:styled-content>), as well as insulin resistance and sensitivity.<\/jats:p><\/jats:sec>Methods<\/jats:title>In all, 100 patients with MS<\/jats:styled-content> (19\u201370\u00a0years of age) who satisfied the W<\/jats:styled-content>orld H<\/jats:styled-content>ealth O<\/jats:styled-content>rganization criteria for MS<\/jats:styled-content> were included in the study. Participants were randomly assigned to receive either oral D<\/jats:styled-content>iamel or a placebo (while maintaining a diet appropriate to their weight and physical activity) at a dose of two capsules before each of the three main meals each day for 1\u00a0year. Anthropometric indices, blood pressure, fasting plasma glucose, lipid profile, insulin, creatinine, and uric acid (UA<\/jats:styled-content>) were determined. Insulin resistance (IR<\/jats:styled-content>) was assessed and three indirect indices were used to calculate insulin sensitivity (IS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with placebo, D<\/jats:styled-content>iamel improved fasting insulin concentrations, IS<\/jats:styled-content>, and IR<\/jats:styled-content> and reduced UA<\/jats:styled-content> concentrations from 6\u00a0months until the end of treatment (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05 for all). In addition, after 12\u00a0months treatment with D<\/jats:styled-content>iamel, significant changes from baseline were seen for mean fasting insulin (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05), UA<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.05), IR<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001), and IS<\/jats:styled-content> (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0.001), whereas no such changes were seen in the placebo\u2010treated group. Improvements were noted in body mass index, IR<\/jats:styled-content>, and IS<\/jats:styled-content> in both groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Long\u2010term D<\/jats:styled-content>iamel treatment, combined with lifestyle changes, was beneficial for IR<\/jats:styled-content> and IS<\/jats:styled-content>, and reduced serum UA<\/jats:styled-content> levels in patients with MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12007","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T10:35:09Z","timestamp":1347878109000},"page":"180-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of D<\/scp>iamel in patients with metabolic syndrome: A randomized double\u2010blind placebo\u2010controlled study (Diamel\u5bf9\u4ee3\u8c22\u7efc\u5408\u5f81\u60a3\u8005\u7684\u5f71\u54cd\uff1a\u4e00\u9879\u968f\u673a\u53cc\u76f2\u5b89\u6170\u5242\u5bf9\u7167\u7814\u7a76)"],"prefix":"10.1111","volume":"5","author":[{"given":"Eduardo","family":"Cabrera\u2010Rode","sequence":"first","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neraldo","family":"Orlandi","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaneysi","family":"Padr\u00f3n","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celeste","family":"Arranz","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raysa","family":"Olano","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"Machado","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Hern\u00e1ndez\u2010Yero","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra\u00fal","family":"Calder\u00edn","sequence":"additional","affiliation":[{"name":"Hermanos Amejeiras Hospital Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma","family":"Dom\u00ednguez","sequence":"additional","affiliation":[{"name":"National Institute of Endocrinology Havana Cuba"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,4,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.539528"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/HCO.0b013e32833cd474"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9136(199807)15:7<539::AID-DIA668>3.0.CO;2-S"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.epirev.a017978"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwf145"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-8-200504190-00009"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-005-0097-z"},{"key":"e_1_2_8_9_1","first-page":"31","article-title":"Tratamientos actuales y futuros del s\u00edndrome","volume":"51","author":"Standl E","year":"2006","journal-title":"Diabetes Voice"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.8.932"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2011.585462"},{"key":"e_1_2_8_12_1","unstructured":"ChetaD TrifanEClinical study regarding the utilization of the preparation Diamel\u00aein the treatment of diabetes mellitus.2012. 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