{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:06:58Z","timestamp":1767006418219},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,5,29]],"date-time":"2013-05-29T00:00:00Z","timestamp":1369785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Based on recent knowledge of the possible involvement of 1,25\u2010dihydroxyvitamin <jats:styled-content style=\"fixed-case\">D<\/jats:styled-content> in the pathogenesis of type 1 diabetes (<jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content>) and the results of its administration in animal models, we conducted a clinical trial by treating high\u2010risk children, positive for <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> autoantibodies, with oral calcitriol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present prospective trial was performed on 12 children (1.5\u201313 years old) who were investigated for the potential risk of <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> because of an already diagnosed association of celiac disease and autoimmune thyroiditis (four girls), autoimmune thyroiditis at a very young age (two girls, two boys), a diagnosis of <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> in siblings (two boys), and impaired glucose tolerance (<jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>; one boy, one girl). Serum autoantibody levels, including islet cell autoantibodies, anti\u2010glutamic acid decarboxylase (<jats:styled-content style=\"fixed-case\">GAD<\/jats:styled-content>) 65, insulin autoantibodies (<jats:styled-content style=\"fixed-case\">IAA<\/jats:styled-content>), and anti\u2010tyrosine phosphatase, and markers of calcium metabolism were evaluated prior to and at 6\u2010monthly intervals after the initiation of 0.25\u2009\u03bcg\/day calcitriol for 1\u20133 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all children, persistent negativation of the anti\u2010<jats:styled-content style=\"fixed-case\">GAD65<\/jats:styled-content> antibodies and <jats:styled-content style=\"fixed-case\">IAA<\/jats:styled-content> was observed within 0.4\u20132.1 years. Of the two children with <jats:styled-content style=\"fixed-case\">IGT<\/jats:styled-content>, the boy proved to have maturity onset diabetes of the young (<jats:styled-content style=\"fixed-case\">MODY<\/jats:styled-content>) 2, whereas the glycemic profile was normalized in the girl.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite the small number of subjects and the absence of a control group in the present study, 0.25\u2009\u03bcg\/day calcitriol effectively negativates anti\u2010<jats:styled-content style=\"fixed-case\">GAD65<\/jats:styled-content> antibodies and <jats:styled-content style=\"fixed-case\">IAA<\/jats:styled-content> after a median time of 6 months. This simple, safe, and low\u2010cost strategy may prove effective in the prevention of <jats:styled-content style=\"fixed-case\">T1D<\/jats:styled-content> in the future.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12023","type":"journal-article","created":{"date-parts":[[2013,1,10]],"date-time":"2013-01-10T09:37:43Z","timestamp":1357810663000},"page":"344-348","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Negativation of type 1 diabetes\u2010associated autoantibodies to glutamic acid decarboxylase and insulin in children treated with oral calcitriol (\u53e3\u670d\u9aa8\u5316\u4e09\u9187\u6cbb\u7597\u7ef4\u6301\u513f\u7ae51\u578b\u7cd6\u5c3f\u75c5\u76f8\u5173\u7684\u8c37\u6c28\u9178\u8131\u7fa7\u9176\u4e0e\u80f0\u5c9b\u7d20\u81ea\u8eab\u6297\u4f53\u9634\u6027)"],"prefix":"10.1111","volume":"5","author":[{"given":"Dimitrios T.","family":"Papadimitriou","sequence":"first","affiliation":[{"name":"3rd 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