{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T01:37:14Z","timestamp":1771033034801,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,4,26]],"date-time":"2013-04-26T00:00:00Z","timestamp":1366934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2013,6]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Genetic determinations are important in type 2 diabetes (T2DM<\/jats:styled-content>) pathology. We investigated associations between genetic variants of 17 diabetes\u2010related genes\/loci, T2DM<\/jats:styled-content> and diabetic complications in C<\/jats:styled-content>hinese S<\/jats:styled-content>he subjects.<\/jats:p><\/jats:sec>Methods<\/jats:title>A comprehensive gene\u2010based association study was conducted using 17 single nucleotide polymorphisms in C<\/jats:styled-content>hinese S<\/jats:styled-content>he subjects with normal glucose tolerance (n<\/jats:italic>\u2009=\u20091119), impaired glucose regulation (n<\/jats:italic>\u2009=\u20091767), and T2DM<\/jats:styled-content> (n<\/jats:italic>\u2009=\u2009443). We applied major abnormal M<\/jats:styled-content>innesota C<\/jats:styled-content>ode findings to predict cardiovascular risk and estimated glomerular filtration rate to assess kidney function.<\/jats:p><\/jats:sec>Results<\/jats:title>Nine variants in FTO<\/jats:styled-content><\/jats:italic> rs8050136, WFS1<\/jats:styled-content><\/jats:italic> rs10010131, CDKN2A\/B<\/jats:styled-content><\/jats:italic> rs10811661, KCNJ11<\/jats:styled-content><\/jats:italic> rs5219, CDC123\/CAMK1D<\/jats:styled-content><\/jats:italic> rs12779790, JAZF1<\/jats:styled-content><\/jats:italic> rs864745, SLC30A8<\/jats:styled-content><\/jats:italic> rs13266634, CDKAL1<\/jats:styled-content><\/jats:italic> rs10946398, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> rs5015480 were significantly associated with T2DM<\/jats:styled-content> (P<\/jats:italic>\u2009<\u20090.05). Single nucleotide polymorphisms in WFS1<\/jats:styled-content><\/jats:italic> rs10010131, CDKN2A\/B<\/jats:styled-content><\/jats:italic> rs10811661, CDC123\/CAMK1D<\/jats:styled-content><\/jats:italic> rs12779790, JAZF1<\/jats:styled-content><\/jats:italic> rs864745, FTO<\/jats:styled-content><\/jats:italic> rs8050136, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> rs5015480 were associated with T2DM<\/jats:styled-content> and impaired glucose regulation. Risk alleles in WFS1<\/jats:styled-content><\/jats:italic> rs10010131, IGF2BP2<\/jats:styled-content><\/jats:italic> rs4402960, CDKAL1<\/jats:styled-content><\/jats:italic> rs10946398, FTO<\/jats:styled-content><\/jats:italic> rs8050136, KCNQ1<\/jats:styled-content><\/jats:italic> rs2237897, and ADAMTS9<\/jats:styled-content><\/jats:italic> rs4607103 were significantly associated with decreased homeostatic model assessment (HOMA<\/jats:styled-content>)\u2010\u03b2 (P<\/jats:italic>\u2009<\u20090.05). After adjusting for age, gender and body mass index, genetic variants JAZF1<\/jats:styled-content><\/jats:italic> rs864745, FTO<\/jats:styled-content><\/jats:italic> rs8050136, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> rs5015480 were significantly related to reduced estimated glomerular filtration rate (P<\/jats:italic>\u2009<\u20090.05). Genetic variants in WFS1<\/jats:styled-content><\/jats:italic> rs10010131, CDKN2A\/B<\/jats:styled-content><\/jats:italic> rs10811661, CDC123\/CAMID<\/jats:styled-content><\/jats:italic> rs12779790, JAZF1<\/jats:styled-content><\/jats:italic> rs864745, FTO<\/jats:styled-content><\/jats:italic> rs80501360, CDKAL1<\/jats:styled-content><\/jats:italic> rs10946398, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> rs5015480 correlated with abnormal major M<\/jats:styled-content>innesota C<\/jats:styled-content>ode findings (P<\/jats:italic>\u2009<\u20090.05).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>Variants in WFS1<\/jats:styled-content><\/jats:italic>, CDKN2A\/B<\/jats:styled-content><\/jats:italic>, KCNJ11<\/jats:styled-content><\/jats:italic>, CDC123\/CAMK1D<\/jats:styled-content><\/jats:italic>, JAZF1<\/jats:styled-content><\/jats:italic>, SLC30A8<\/jats:styled-content><\/jats:italic>, FTO<\/jats:styled-content><\/jats:italic>, CDKAL1<\/jats:styled-content><\/jats:italic>, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> genes are significantly associated with T2DM<\/jats:styled-content> in S<\/jats:styled-content>he C<\/jats:styled-content>hinese subjects. JAZF1<\/jats:styled-content><\/jats:italic>, FTO<\/jats:styled-content><\/jats:italic>, CDKAL1<\/jats:styled-content><\/jats:italic>, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> are associated with diabetic nephropathy. WFS1<\/jats:styled-content><\/jats:italic>, CDKN2A\/B<\/jats:italic><\/jats:styled-content>, CDC123\/CAMK1D<\/jats:styled-content><\/jats:italic>, JAZF1<\/jats:styled-content><\/jats:italic>, FTO<\/jats:styled-content><\/jats:italic>, CDKAL1<\/jats:styled-content><\/jats:italic>, and HHEX\/IDE<\/jats:styled-content><\/jats:italic> are associated with cardiovascular risk.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12025","type":"journal-article","created":{"date-parts":[[2013,1,9]],"date-time":"2013-01-09T18:09:24Z","timestamp":1357754964000},"page":"136-145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Association study of genetic variants of 17 diabetes\u2010related genes\/loci and cardiovascular risk and diabetic nephropathy in the C<\/scp>hinese S<\/scp>he population (\u4e2d\u56fd\u7572\u65cf\u4eba\u7fa417\u4e2a\u7cd6\u5c3f\u75c5\u76f8\u5173\u57fa\u56e0\u4f4d\u70b9\u7684\u9057\u4f20\u53d8\u5f02\u4e0e\u5fc3\u8840\u7ba1\u98ce\u9669\u548c\u7cd6\u5c3f\u75c5\u80be\u75c5\u7684\u76f8\u5173\u6027)"],"prefix":"10.1111","volume":"5","author":[{"given":"Gang","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology Fujian Provincial Hospital Fujian Medical University Fujian Provincial Hospital Key Laboratory of Endocrinology Fuzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Provincial Hospital Fujian Medical University Fujian Provincial Hospital Key Laboratory of Endocrinology Fuzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghua","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Ningde Municipal Hospital Fujian Medical University Ningde China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Provincial Hospital Fujian Medical University Fujian Provincial Hospital Key Laboratory of Endocrinology Fuzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Provincial Hospital Fujian Medical University Fujian Provincial Hospital Key Laboratory of Endocrinology Fuzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baoying","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Ningde Municipal Hospital Fujian Medical University Ningde China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zichun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Ningde Municipal Hospital Fujian Medical University Ningde China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huibin","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Provincial Hospital Fujian Medical University Fujian Provincial Hospital Key Laboratory of Endocrinology Fuzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianguo","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Ningde Municipal Hospital Fujian Medical University Ningde China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Fujian Provincial Hospital Fujian Medical University Fujian Provincial Hospital Key Laboratory of Endocrinology Fuzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghan","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pathology, 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