{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T03:23:45Z","timestamp":1773285825250,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2013,10,29]],"date-time":"2013-10-29T00:00:00Z","timestamp":1383004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"crossref","award":["NCT00825643"],"award-info":[{"award-number":["NCT00825643"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"crossref","award":["NCT00740519"],"award-info":[{"award-number":["NCT00740519"]}],"id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to identify demographic and treatment factors that were predictive of hypoglycemia in a large cohort of type 2 diabetic patients initiating insulin detemir.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present 24\u2010week observational study of insulin initiation included 17\u2009374 participants from 10 countries. Severe hypoglycemia was defined as an event requiring third party assistance; minor hypoglycemia was defined as a daytime or nocturnal glucose measurement &lt;3.1\u2009mmol\/L.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Prior to initiating insulin therapy, 4.9% of the cohort reported hypoglycemia (pre\u2010insulin hypoglycemia), with most (94.2%) reporting minor events and 9.6% reporting severe events. Compared with patients without pre\u2010insulin hypoglycemia, those with pre\u2010insulin hypoglycemia had a higher incidence of events of minor hypoglycemia (1.72 vs 4.46 events per patient\u2010year [ppy], respectively), nocturnal hypoglycemia (0.25 vs 1.09 events ppy, respectively), and severe hypoglycemia (&lt;0.01 vs 0.04 events ppy, respectively) at final visit. Age (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.047), body mass index (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), a prior history of microvascular disease (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), pre\u2010insulin hypoglycemia (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), increased number of oral hypoglycemic agents (<jats:styled-content style=\"fixed-case\">OHAs<\/jats:styled-content>; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), <jats:styled-content style=\"fixed-case\">OHA<\/jats:styled-content> intensification (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), and the use of glinides (<jats:italic>P<\/jats:italic>\u2009=\u20090.004) were all found to be independently associated with the occurrence of hypoglycemia during the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Once\u2010daily insulin detemir therapy was safe and effective, and rates of hypoglycemia were low. Concerns about hypoglycemia should not deter the initiation of basal insulin analogs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12091","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T13:56:40Z","timestamp":1381240600000},"page":"243-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety of once\u2010daily insulin detemir in patients with type 2 diabetes treated with oral hypoglycemic agents in routine clinical practice (\u5728\u5e38\u89c4\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u4f7f\u7528\u53e3\u670d\u964d\u7cd6\u836f\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u6bcf\u65e5\u4e00\u6b21\u4f7f\u7528\u5730\u7279\u80f0\u5c9b\u7d20\u6cbb\u7597\u7684\u5b89\u5168\u6027)"],"prefix":"10.1111","volume":"6","author":[{"given":"Stuart","family":"Ross","sequence":"first","affiliation":[{"name":"Department of Medicine University of Calgary  Calgary 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