{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T18:47:00Z","timestamp":1774982820229,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,11,26]],"date-time":"2013-11-26T00:00:00Z","timestamp":1385424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The aim of the present study was to assess the efficacy of structured education in insulin\u2010treated type 2 diabetes mellitus (T2DM<\/jats:styled-content>) patients.<\/jats:p><\/jats:sec>Methods<\/jats:title>In a 16\u2010week open\u2010label randomized controlled study, 1511 T2DM<\/jats:styled-content> patients with inadequate responses to two or more oral antidiabetic drugs (OADs<\/jats:styled-content>) for >3 months (HbA1c<\/jats:styled-content> >7.5%) were randomized (1:1) to either an education group (structured diabetes education plus insulin therapy) or a control group (usual care plus insulin therapy). Both groups discontinued previous OADs<\/jats:styled-content> (except biguanides and \u03b1\u2010glucosidase inhibitors) and started twice daily injections of 30% soluble\u201370% isophane recombinant insulin. The primary endpoint was the change in HbA1c<\/jats:styled-content> from baseline. Efficacy and safety data were analyzed for within\u2010 and between\u2010group differences.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the initial 1511 patients, 1289 completed the study (643 in the control group; 646 in the education group). At the end of the study, significant reductions in HbA1c<\/jats:styled-content> versus baseline were evident in both groups, but the reduction was greater in the education group (2.16% vs 2.08%; P<\/jats:italic>\u2009<\u20090.05). A higher proportion of patients in the education group achieved target HbA1c<\/jats:styled-content> levels <7% (43.81% vs 36.86%; P<\/jats:italic>\u2009<\u20090.05) and \u22646.5% (28.48% vs 22.71%; P<\/jats:italic>\u2009<\u20090.05). In addition, patients in the education group showed greater increments in scores and improvement in the M<\/jats:styled-content>orisky Medication Adherence Scale (P<\/jats:italic>\u2009<\u20090.05). The overall incidence of hypoglycemic events was similar in the two groups.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Structured education can promote the ability of patients to self\u2010manage and their compliance with medications, thereby achieving better outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12100","type":"journal-article","created":{"date-parts":[[2013,10,23]],"date-time":"2013-10-23T17:02:22Z","timestamp":1382547742000},"page":"290-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Efficacy of structured education in patients with type 2 diabetes mellitus receiving insulin treatment (\u7ed3\u6784\u5316\u6559\u80b2\u5bf9\u63a5\u53d7\u80f0\u5c9b\u7d20\u6cbb\u7597\u76842\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u6548\u679c)"],"prefix":"10.1111","volume":"6","author":[{"given":"Xiao Hui","family":"Guo","sequence":"first","affiliation":[{"name":"Peking University First Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li Nong","family":"Ji","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ju Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"Chinese People's Liberation Army General Hospital of Beijing Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Shanxi Province People's Hospital Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing Qing","family":"Lou","sequence":"additional","affiliation":[{"name":"Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Gansu Province People's Hospital Lanzhou 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