{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:53:24Z","timestamp":1781880804570,"version":"3.54.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,1,9]],"date-time":"2014-01-09T00:00:00Z","timestamp":1389225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To demonstrate whether abnormal glucose metabolism (diabetes and prediabetes) is associated with increased risk for cancer in the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese population and to identify factors that modify the risk of cancer among individuals with abnormal glucose metabolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between 2011 and 2012, 259\u2009657 community\u2010dwelling adults, aged 40 years and older, were recruited from 25 centers across mainland <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina to participant in the baseline survey of the <jats:styled-content style=\"fixed-case\">REACTION<\/jats:styled-content> study, with follow\u2010up investigations performed 3, 5, and 10 years later. Detailed questionnaires about lifestyles, physical and biochemical measurement, bio\u2010samples including serum, urine, and whole blood for <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> extraction were collected for all the participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean \u00b1 standard deviation (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>) age of this cohort was 57\u2009\u00b1\u200910 years. And the prevalence of pre\u2010existing and newly diagnosed diabetes was 10.32% and 10.57%, respectively. A total of 4511 prevalent cancer cases (988 men and 3523 women) were identified, the prevalence was 1.79. Compared to those with normal glucose metabolism, men with diabetes had a significantly lower adjusted prevalence ratio (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>) of stomach cancer (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>: 0.38, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 0.16\u20130.89), and women with diabetes had significantly higher adjusted <jats:styled-content style=\"fixed-case\">PRs<\/jats:styled-content> of cancer of all sites (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>: 1.36, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.20\u20131.56), and cancer of the breast (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>: 1.56, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.21\u20132.00), the endometrium (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>: 1.58, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.16\u20132.15), and the thyroid (<jats:styled-content style=\"fixed-case\">PR<\/jats:styled-content>: 1.53, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 1.03\u20132.27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The multi\u2010center <jats:styled-content style=\"fixed-case\">REACTION<\/jats:styled-content> study has captured a broad range of data on physical, psychological and metabolic function as well as health status, biochemical and lifestyle information in 259\u2009657 adults from the general population across the <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12108","type":"journal-article","created":{"date-parts":[[2013,11,14]],"date-time":"2013-11-14T13:02:42Z","timestamp":1384434162000},"page":"147-157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":171,"title":["Cohort profile: Risk evaluation of cancers in <scp>C<\/scp>hinese diabetic individuals: a longitudinal (<scp>REACTION<\/scp>) study (\u961f\u5217\u7b80\u4ecb\uff1a\u4e2d\u56fd\u7cd6\u5c3f\u75c5\u60a3\u8005\u80bf\u7624\u53d1\u751f\u98ce\u9669\u7684\u7eb5\u5411\u7814\u7a76\uff08REACTION\u7814\u7a76\uff09)"],"prefix":"10.1111","volume":"6","author":[{"given":"Yufang","family":"Bi","sequence":"first","affiliation":[{"name":"Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui\u2010Jin Hospital Shanghai Jiao\u2010Tong University School of Medicine E\u2010Institute of Shanghai Universities  Shanghai 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