{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T22:51:01Z","timestamp":1769813461390,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2013,12,17]],"date-time":"2013-12-17T00:00:00Z","timestamp":1387238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2014,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The relationship between albumin\u2009:\u2009creatinine ratio (ACR<\/jats:styled-content>), insulin resistance (IR<\/jats:styled-content>), cytokines, dyslipidemia, and 25\u2010hydroxy vitamin D<\/jats:styled-content> (25\u2010OHD<\/jats:styled-content>) in individuals with prediabetes (IPD<\/jats:styled-content>) was investigated to evaluate their role in predicting future risk of progression to diabetes.<\/jats:p><\/jats:sec>Methods<\/jats:title>The aforementioned parameters were evaluated in 147 IPD<\/jats:styled-content> with persistent impaired fasting glucose and\/or impaired glucose tolerance over two oral glucose tolerance tests, who were then followed up at 3\u2010monthly intervals for progression to diabetes or reversal to normoglycemia.<\/jats:p><\/jats:sec>Results<\/jats:title>Data were analyzed for 137 IPD<\/jats:styled-content> with at least 1\u2010year follow\u2010up. Forty\u2010three IPD<\/jats:styled-content> reversed to normoglycemia (G<\/jats:styled-content>roup I<\/jats:styled-content>), 69 continued with prediabetes (G<\/jats:styled-content>roup II<\/jats:styled-content>), and 25 progressed to diabetes (G<\/jats:styled-content>roup III<\/jats:styled-content>) over a mean follow\u2010up period of 28.36\u2009\u00b1\u20098.19 months. Baseline fasting blood glucose levels (BGLs<\/jats:styled-content>), 2\u2010h post\u2010glucose BGLs<\/jats:styled-content>, and ACR<\/jats:styled-content> were lowest in Group I<\/jats:styled-content> and highest in G<\/jats:styled-content>roup III<\/jats:styled-content>. Of the 137 IPD<\/jats:styled-content>, 54.75% (n<\/jats:italic>\u2009=\u200975) had microalbuminuria. The IPD<\/jats:styled-content> in the lowest ACR<\/jats:styled-content> quartile had the highest reversal to normoglycemia. Cox regression revealed that baseline IL<\/jats:styled-content>\u20106 was predictive of progression to diabetes (P<\/jats:italic>\u2009=\u20090.03) and ACR<\/jats:styled-content> was an independent predictor of reversal to normoglycemia (P<\/jats:italic>\u2009=\u20090.007). K<\/jats:styled-content>aplan\u2013M<\/jats:styled-content>eier analysis showed higher reversal to normoglycemia in IPD<\/jats:styled-content> without microalbuminuria (P<\/jats:italic>\u2009<\u20090.001).<\/jats:p><\/jats:sec>Conclusion<\/jats:title>An increased ACR<\/jats:styled-content> is associated with higher creatinine, IR<\/jats:styled-content>, and cytokine levels and lower 25\u2010OHD<\/jats:styled-content> levels in IPD<\/jats:styled-content>. Microalbuminuria is associated with decreased reversal to normoglycemia and increased progression to diabetes. Low 25\u2010OHD<\/jats:styled-content> may be associated with increased progression to diabetes, perhaps via modulation of the ACR<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12112","type":"journal-article","created":{"date-parts":[[2013,11,20]],"date-time":"2013-11-20T11:12:50Z","timestamp":1384945970000},"page":"316-322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Urinary albumin\u2009:\u2009creatinine ratio predicts prediabetes progression to diabetes and reversal to normoglycemia: Role of associated insulin resistance, inflammatory cytokines and low vitamin D<\/scp> 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