{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T06:10:48Z","timestamp":1696227048995},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2014,3,11]],"date-time":"2014-03-11T00:00:00Z","timestamp":1394496000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2014,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The association of inflammation with cardiovascular (CV<\/jats:styled-content>) complications in diabetes remains a matter of considerable debate. Arterial stiffness and enhanced wave reflection play an important role in CV<\/jats:styled-content> complications. Therefore, in the present study we investigated whether markers of inflammation are correlated with parameters of wave reflection in type 1 diabetes (T1D<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>In all, 145 T1D<\/jats:styled-content> patients were included in the study (median age 32 years, disease duration 10 years, HbA1c<\/jats:styled-content> 8.2%). Serum concentrations of high\u2010sensitivity C<\/jats:styled-content>\u2010reactive protein (hs\u2010CRP<\/jats:styled-content>), matrix metalloproteinase (MMP<\/jats:styled-content>)\u20109, soluble intracellular adhesion molecule\u20101 (sICAM<\/jats:styled-content>\u20101), and myeloperoxidase (MPO<\/jats:styled-content>) were estimated as markers of inflammation. Parameters of pulse wave reflection (central augmentation index [cAIx<\/jats:styled-content>] and peripheral augmentation index [pAIx<\/jats:styled-content>]) were assessed using pulse wave analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Multivariate linear regression analysis revealed that, after adjustment for age, mean blood pressure, HbA1c<\/jats:styled-content>, low\u2010density lipoprotein\u2013cholesterol, and the presence of at least one microangiopathic complication of diabetes, cAIx<\/jats:styled-content> and pAIx<\/jats:styled-content> were associated with serum concentration of hs\u2010CRP<\/jats:styled-content> (\u03b2\u2009=\u20091.838, 95% confidence interval [CI<\/jats:styled-content>] 0.336\u20133.339 [P<\/jats:italic>\u2009=\u20090.017]; and \u03b2\u2009=\u20092.041, 95% CI<\/jats:styled-content> 0.683\u20133.400 [P<\/jats:italic>\u2009=\u20090.004], respectively) and sICAM<\/jats:styled-content>\u20101 (\u03b2\u2009=\u20090.073, 95% CI<\/jats:styled-content> 0.015\u20130.131 [P<\/jats:italic>\u2009=\u20090.014]; and \u03b2\u2009=\u20090.066, 95% CI<\/jats:styled-content> 0.013\u20130.119 [P<\/jats:italic>\u2009=\u20090.016], respectively) in the study group.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In T1D<\/jats:styled-content> parameters of wave reflection are related to markers of inflammation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12129","type":"journal-article","created":{"date-parts":[[2014,1,24]],"date-time":"2014-01-24T07:51:26Z","timestamp":1390549886000},"page":"577-585","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["C\u2010R<\/scp>eactive protein and soluble intracellular adhesion molecule\u20101 are related to pulse wave reflection in type 1 diabetes 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