{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:04:31Z","timestamp":1762542271016},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,4,21]],"date-time":"2014-04-21T00:00:00Z","timestamp":1398038400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The insulin\u2010like growth factor 2 mRNA<\/jats:styled-content>\u2010binding protein 2 (IGF2BP2<\/jats:styled-content><\/jats:italic>) and the cyclin\u2010dependent kinase 5 regulatory subunit\u2010associated protein 1\u2010like 1 (CDKAL1<\/jats:styled-content><\/jats:italic>) identified through genome\u2010wide association (GWA<\/jats:styled-content>) studies have been shown to be associated with Type 2 diabetes in various ethnic groups. In this study, we investigated the association of the rs7756992 of CDKAL1<\/jats:styled-content><\/jats:italic> and the rs4402960 of IGF2BP2<\/jats:styled-content><\/jats:italic> with Type 2 diabetes, diabetic complications (nephropathy, retinopathy and cardiovascular disease), obesity and hypertension in a Tunisian population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A case\u2010control association study including 200 Type 2 diabetes T<\/jats:styled-content>unisian patients (W<\/jats:styled-content>orld H<\/jats:styled-content>ealth O<\/jats:styled-content>rganization criteria) and 208 controls (age \u226540; fasting plasma glucose <6.1\u2009mmol\/L; without first degree family history of diabetes) has been performed. Other parameters such as diabetic nephropathy, diabetic retinopathy, cardiovascular disease, overweight\/obesity and hypertension have been also collected. Genotyping was performed using TaqMan<\/jats:styled-content> technology.<\/jats:p><\/jats:sec>Results<\/jats:title>A significant association between the rs4402960 and Type 2 diabetes (OR<\/jats:styled-content> = 1.86, 95% CI<\/jats:styled-content> = 1.34\u20132.58, P<\/jats:italic> < 10\u22124<\/jats:sup>) has been found. Overweight\/obese subjects bearing the T\u2010allele have an increased risk to develop Type 2 diabetes (OR<\/jats:styled-content> = 2.06, 95% CI<\/jats:styled-content> = 1.40\u20133.03, P<\/jats:italic> < 10\u22124<\/jats:sup>). Furthermore, the rs7756992 was found to be associated with the reduced risk of diabetic nephropathy in patients with diabetes (OR<\/jats:styled-content> = 0.44, 95% CI<\/jats:styled-content> = 0.27\u20130.73, P<\/jats:italic> = 0.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>The present study confirms that the rs4402960 of IGF2BP2<\/jats:styled-content><\/jats:italic> gene is a strong candidate for Type 2 diabetes susceptibility and overweight\/obesity risk in the T<\/jats:styled-content>unisian population. Interestingly, our data suggest that the rs7756992 of CDKAL1<\/jats:styled-content><\/jats:italic> gene have a protective effect against diabetic nephropathy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12147","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T08:14:41Z","timestamp":1395130481000},"page":"102-113","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Contribution of CDKAL1<\/scp><\/i> rs7756992 and IGF2BP2<\/scp><\/i> rs4402960 polymorphisms in type 2 diabetes, diabetic complications, obesity risk and hypertension in the T<\/scp>unisian population \u5728\u7a81\u5c3c\u65af\u4eba\u7fa4\u4e2d\uff0cCDKAL1<\/i> rs7756992\u4e0eIGF2BP2<\/i> rs4402960\u7684\u591a\u6001\u6027\u5bf92\u578b\u7cd6\u5c3f\u75c5\u3001\u7cd6\u5c3f\u75c5\u5e76\u53d1\u75c7\u3001\u80a5\u80d6\u98ce\u9669\u4ee5\u53ca\u9ad8\u8840\u538b\u7684\u5f71\u54cd"],"prefix":"10.1111","volume":"7","author":[{"given":"Khaled","family":"Lasram","sequence":"first","affiliation":[{"name":"Biomedical Genomics and Oncogenetics Laboratory (LR 11 IPT 05) Institut Pasteur de Tunis Universit\u00e9 El Manar de Tunis Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nizar","family":"Ben Halim","sequence":"additional","affiliation":[{"name":"Biomedical Genomics and Oncogenetics Laboratory (LR 11 IPT 05) Institut Pasteur de Tunis Universit\u00e9 El Manar de Tunis Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Houda","family":"Benrahma","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular and Human Genetics Department of Scientific Research Institut Pasteur du Maroc Casablanca 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11 IPT 05) Institut Pasteur de Tunis Universit\u00e9 El Manar de Tunis Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henda","family":"Jamoussi","sequence":"additional","affiliation":[{"name":"Biomedical Genomics and Oncogenetics Laboratory (LR 11 IPT 05) Institut Pasteur de Tunis Universit\u00e9 El Manar de Tunis Tunis Tunisia"},{"name":"Department of External Consultation National Institute of Nutrition and Food Technology Universit\u00e9 El Manar de Tunis Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slim","family":"Ben Ammar","sequence":"additional","affiliation":[{"name":"Central Laboratory of Medical Biology Institut Pasteur de Tunis Universit\u00e9 El Manar de Tunis Tunis Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Bahri","sequence":"additional","affiliation":[{"name":"Central Laboratory of Medical Biology Institut Pasteur de Tunis Universit\u00e9 El Manar de Tunis 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