{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:26Z","timestamp":1790140586745,"version":"4.0.1"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Novartis Pharma, Beijing, China"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present study was to investigate the current status of oral anti\u2010diabetic drug (<jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content>) therapy in patients with type 2 diabetes and influencing factors in a real\u2010world setting in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 9872 outpatients with type 2 diabetes, who had received <jats:styled-content style=\"fixed-case\">OADs<\/jats:styled-content> (monotherapy or combination therapy) for at least 3 months were recruited in this study. Current antidiabetic treatment regimen and related clinical data were collected from medical records and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common <jats:styled-content style=\"fixed-case\">OADs<\/jats:styled-content> in use were insulin secretagogues (70.2%) such as sulfonylureas (<jats:styled-content style=\"fixed-case\">SUs<\/jats:styled-content>; 42.7%) or glinides (27.5%), followed by metformin (53.7%), \u03b1\u2010glucosidase inhibitors (35.9%), thiazolidinediones (17.2%), and dipeptidyl peptidase\u20104 (<jats:styled-content style=\"fixed-case\">DPP<\/jats:styled-content>\u20104) inhibitors (0.8%). Dual\u2010drug combination therapy was more common (45.4%) than monotherapy (35.8%) and combination therapy with at least three drugs (17.0%). Patients on <jats:styled-content style=\"fixed-case\">SU<\/jats:styled-content> or glinide monotherapy were more likely to alter their treatment frequently (odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>], 1.7; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.38\u20132.08; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The status of <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> use in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina is varied with a majority of the patients altering their treatment regimen citing poor effectiveness. These observations from a real\u2010world setting may serve as guidance for improving diabetes management in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hina.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12165","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T10:57:02Z","timestamp":1399633022000},"page":"166-173","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["<scp>C<\/scp>hina type 2 diabetes treatment status survey of treatment pattern of oral drugs users"],"prefix":"10.1111","volume":"7","author":[{"given":"Linong","family":"Ji","sequence":"first","affiliation":[{"name":"Department of Endocrinology Peking University People's Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Chinese PLA General Hospital  Beijing 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