{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:01:10Z","timestamp":1740153670208,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170751","81370954","81200294"],"award-info":[{"award-number":["81170751","81370954","81200294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100013286","name":"Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"crossref","award":["20125503110010"],"award-info":[{"award-number":["20125503110010"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Key Clinical Specialties Construction Program of China"},{"name":"New Drug Development, Construction and Management of Clinical Biobank for Major Disease","award":["2011ZX0907-001-08"],"award-info":[{"award-number":["2011ZX0907-001-08"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Insulin therapy should be strongly considered in newly diagnosed type 2 diabetic (<jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content>) patients with severe hyperglycemia. However, whether insulin be continued or patients switched to an oral antidiabetic drug (<jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content>) after short\u2010term intensive insulin therapy (<jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>) is not clear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After <jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content> for 10\u201314 days, 47 patients were randomized into either a glargine (<jats:italic>n<\/jats:italic>\u2009=\u200921) or metformin\u2010based <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u2009=\u200926) group for a 6\u2010month intervention. After these 6 months, patients in the glargine group were switched to metformin\u2010based <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> therapy, whereas treatment in the <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> group was unchanged. Patients were followed\u2010up for another 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>t the end of the 6\u2010month intervention, <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content> was similarly reduced in both the glargine (from 11.81\u2009\u00b1\u20091.70% to 6.48\u2009\u00b1\u20090.79%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> (from 11.71\u2009\u00b1\u20091.89% to 6.16\u2009\u00b1\u20090.52%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) groups. At the end of 12 months, HbA1c was at comparable and near optimal levels in both groups. Similar increases were seen in homeostatic model assessment of <jats:italic>\u03b2<\/jats:italic>\u2010cell function in the two groups after 6 months. There were no significant differences between the two groups in insulin sensitivity improvement, hypoglycemic episodes, weight change, treatment satisfaction and quality of life after the 6\u2010month intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The effects of metformin\u2010based <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> therapy on glycemic control and improvements in <jats:italic>\u03b2<\/jats:italic>\u2010cell function are not inferior to glargine in newly diagnosed <jats:styled-content style=\"fixed-case\">T2D<\/jats:styled-content> patients with severe hyperglycemia after short\u2010term <jats:styled-content style=\"fixed-case\">ITT<\/jats:styled-content>. Considering the superiority of metformin in terms of safety, cost, and convenience, metformin\u2010based <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> therapy is strongly recommended for these patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12167","type":"journal-article","created":{"date-parts":[[2014,5,14]],"date-time":"2014-05-14T09:54:44Z","timestamp":1400061284000},"page":"182-191","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of metformin\u2010based oral antidiabetic drugs is not inferior to insulin glargine in newly diagnosed type 2 diabetic patients with severe hyperglycemia after short\u2010term intensive insulin therapy"],"prefix":"10.1111","volume":"7","author":[{"given":"Qingfeng","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University  Chongqing 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