{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T16:01:10Z","timestamp":1740153670485,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T00:00:00Z","timestamp":1409788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The present subanalysis of the Study of Once Daily Levemir (<jats:styled-content style=\"fixed-case\">SOLVE<\/jats:styled-content>) study was to evaluate the safety and efficacy of once\u2010daily insulin detemir as add\u2010on to oral antidiabetic drugs (<jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content>s) in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese type 2 diabetes patients according to body mass index in a real\u2010life setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 3272 eligible patients who were treated with diet, exercise, and one or more <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content> were prescribed once\u2010daily insulin detemir by their physician according to routine clinical practice and were followed\u2010up for 24 weeks. The incidence of serious adverse reactions (<jats:styled-content style=\"fixed-case\">SADR<\/jats:styled-content>s), including major hypoglycemia, was the primary endpoint. Subanalyses were performed on patients in the following <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> groups: normal weight (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2009&lt;\u200925\u2009kg\/m<jats:sup>2<\/jats:sup>); overweight (25\u2009\u2264\u2009<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2009&lt;\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>); and obese (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u2009\u2265\u200930\u2009kg\/m<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No <jats:styled-content style=\"fixed-case\">SADRs<\/jats:styled-content> were reported during the study. Significant improvements in glycemic levels were observed in all subgroups. For normal weight, overweight, and obese patients, the mean change in <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content> (%\/[mmol\/mol]) was \u22121.26\/\u221214, \u22121.09\/\u221212, and \u22121.06\/\u221212, respectively. The mean change in fasting plasma glucose in normal weight, overweight, and obese patients was \u22122.77, \u22122.57, and \u22122.71\u2009mmol\/L, respectively. Slight weight gain (0.25\u2009kg), slight weight loss (\u20130.36\u2009kg), and weight loss (\u20131.32\u2009kg) were observed in the normal weight, overweight, and obese patients, respectively (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Linear regression analysis revealed a negative relationship between weight change and baseline <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> (slope\u2009=\u2009\u22120.16; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Once\u2010daily insulin detemir as add\u2010on to <jats:styled-content style=\"fixed-case\">OAD<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese patients with type 2 diabetes showed effective glycemic control and a low risk of hypoglycemia. Weight\u2010neutral effects were observed in different <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> subgroups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12179","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T11:23:05Z","timestamp":1402312985000},"page":"222-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Weight\u2010neutral effect of once\u2010daily insulin detemir in <scp>C<\/scp>hinese type 2 diabetes patients: Subgroup analysis of the <scp>SOLVE<\/scp> study \u4e00\u5929\u4e00\u6b21\u5730\u7279\u80f0\u5c9b\u7d20\u5bf9\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f53\u91cd\u7684\u4e2d\u6027\u5f71\u54cd\uff1aSOLVE\u7814\u7a76\u4e9a\u7ec4\u5206\u6790"],"prefix":"10.1111","volume":"7","author":[{"given":"Changyu","family":"Pan","sequence":"first","affiliation":[{"name":"Chinese PLA General Hospital  Beijing 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