{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T13:11:11Z","timestamp":1723036271935},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fondo de Investigacion Sanitaria, Ministerio de Sanidad y Consumo, Spain","award":["11\/00811"],"award-info":[{"award-number":["11\/00811"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>One of the earliest signs of dysfunction in a complex system is the simplification of its output. A well\u2010accepted method to measure this phenomenon is detrended fluctuation analysis (DFA<\/jats:styled-content>). Herein, we evaluated the usefulness of DFA<\/jats:styled-content> at the threshold of type 2 diabetes mellitus (T2DM<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We report on the clinical and glucometric characteristics of a sample of 103 patients at increased risk of developing T2DM<\/jats:styled-content>. All patients had HbA1c<\/jats:styled-content> levels 5%\u20136.4% and met at least one of the following criteria: body mass index (BMI<\/jats:styled-content>)\u2009>\u200930\u2009kg\/m2<\/jats:sup>, essential hypertension or a first\u2010degree relative with T2DM<\/jats:styled-content>. For each patient, a 24\u2010h glucose time series was obtained, and the clinical and glucometric variables were compared.<\/jats:p><\/jats:sec>Results<\/jats:title>There was a significant correlation between the number of N<\/jats:styled-content>ational C<\/jats:styled-content>holesterol E<\/jats:styled-content>ducation P<\/jats:styled-content>rogram \u2013 A<\/jats:styled-content>dult T<\/jats:styled-content>reatment P<\/jats:styled-content>anel (ATP III<\/jats:styled-content>) metabolic syndrome (MS<\/jats:styled-content>)\u2010defining criteria and DFA<\/jats:styled-content> (\u03c1\u2009=\u20090.231, P<\/jats:italic>\u2009=\u20090.019), and DFA<\/jats:styled-content> differed significantly between patients meeting or not the ATP III<\/jats:styled-content> definition of MS<\/jats:styled-content> (1.443 vs 1.399, respectively; P<\/jats:italic>\u2009=\u20090.018). The DFA<\/jats:styled-content> was not correlated with HbA1c. Depending on how it was calculated, the area under the log(F<\/jats:styled-content>n)\u223clog(n) curve correlated with HbA1c<\/jats:styled-content> levels or the number of MS<\/jats:styled-content> criteria. Conventional variability metrics (mean amplitude of glycemic excursions) did not differ between patients complying or not with the definition of MS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Complexity analysis is capable of detecting differences in variables related to the risk of developing T2DM<\/jats:styled-content> and could be a useful tool to study the initial phases of glucoregulatory dysfunction leading to T2DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12182","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T11:23:05Z","timestamp":1402312985000},"page":"287-293","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Glucose series complexity at the threshold of diabetes \u7cd6\u5c3f\u75c5\u9608\u503c\u7684\u8840\u7cd6\u5e8f\u5217\u7684\u590d\u6742\u6027"],"prefix":"10.1111","volume":"7","author":[{"given":"Manuel","family":"Varela","sequence":"first","affiliation":[{"name":"Department of Internal Medicine University Hospital of Mostoles Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Mostoles Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Vigil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Mostoles Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Cirugeda","sequence":"additional","affiliation":[{"name":"Computer Science Department (DISCA) Polytechnic University of Valencia Alcoi Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Colas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Mostoles Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Borja","family":"Vargas","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine University Hospital of Mostoles Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.12.2142"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(97)00516-X"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.97.20.2031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(98)01076-5"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.20.2079"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0779(95)80025-C"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.01.001"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1992.03480130122036"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-006-0226-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1997.82.1.262"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1353\/pbm.2010.0003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S3812"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.169404"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.166141"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.23.e215"},{"key":"e_1_2_8_17_1","unstructured":"Wikipedia.Map\u2013territory relation[updated 26 January 2014].2014. 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