{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T22:51:53Z","timestamp":1790549513236,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,10]],"date-time":"2014-09-10T00:00:00Z","timestamp":1410307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Fundaci\u00ef\u00bf\u00bdn SEEN"},{"name":"Instituto de Salud Carlos III (ISCIII)","award":["FIS 12\/00803"],"award-info":[{"award-number":["FIS 12\/00803"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There is growing evidence suggesting a deleterious effect of type 2 diabetes on lung function and sleep breathing. The aim of this case\u2010control study was to evaluate whether or not an improvement in glycemic control could arrest or ameliorate nocturnal hypoxemia in type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty patients with type 2 diabetes with <jats:styled-content style=\"fixed-case\">HbA1c<\/jats:styled-content> \u22658% (cases) and 10 non\u2010diabetic subjects were analyzed. Controls were closely matched to cases by age, gender, body mass index, and neck circumference. The nocturnal oxygen desaturation index (<jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>) was calculated at baseline and 5 days after blood glucose improvement with pharmacological intervention. Four different oxygen desaturation thresholds (reductions in <jats:styled-content style=\"fixed-case\"><jats:roman>SaO<jats:sub>2<\/jats:sub><\/jats:roman><\/jats:styled-content>\u2009\u2265\u20093%, 4%, 6%, and 8%) as indicators of hypoxemia severity (<jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20103%, <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20104%, <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20106%, <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20108%) were used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, patients with diabetes showed a higher number of <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20103%, <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20104%, and <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20106% in comparison with controls. A significant reduction in <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content>\u20103% (29.7 [4.8\u2013107.9] events per hour at baseline <jats:italic>versus<\/jats:italic> 24.6 [3.1\u201397.7] e\/h at discharge, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), ODI\u20104% (21.7 [1.6\u201379.3] <jats:italic>versus<\/jats:italic> 14.7 [0.3\u2013 79.4], <jats:italic>P<\/jats:italic>\u2009=\u20090.003), ODI\u20106% (9.3 [0.3\u201371.8] <jats:italic>versus<\/jats:italic> 4.0 [0.0\u201373.7], <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and ODI\u20108% (4.1 [0.0\u201364.3] <jats:italic>versus<\/jats:italic> 1.1 [0.0\u201369.8], <jats:italic>P<\/jats:italic>\u2009=\u20090.033) was observed in patients with diabetes after 5 days of follow\u2010up. However, no changes in <jats:styled-content style=\"fixed-case\">ODI<\/jats:styled-content> events were observed in non\u2010diabetic patients after the same period. No significant changes in weight were observed in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Glycemic control improvement significantly reduces the increased number of nocturnal oxygen desaturations that exist in type 2 diabetes. Although the mechanisms are not yet fully understood, the rapid effect without changes in body weight suggests a central mechanism involving respiratory center output.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12197","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T19:32:46Z","timestamp":1405452766000},"page":"133-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Effect of glycemic control on nocturnal arterial oxygen saturation: A case\u2010control study in type 2 diabetic patients \u8840\u7cd6\u63a7\u5236\u5bf9\u591c\u95f4\u52a8\u8109\u8840\u6c27\u9971\u548c\u5ea6\u7684\u5f71\u54cd\uff1a\u4e00\u98792\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76"],"prefix":"10.1111","volume":"7","author":[{"given":"Albert","family":"Lecube","sequence":"first","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Instituto de Salud Carlos III (ISCIII) Endocrinology Department Diabetes and Metabolism Research Unit Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"},{"name":"Endocrinology and Nutrition Department Arnau de Vilanova University Hospital Universitat de Lleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Ciudin","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Instituto de Salud Carlos III (ISCIII) Endocrinology Department Diabetes and Metabolism Research Unit Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Sampol","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Respiratorias (CIBERES) Instituto de Salud Carlos III (ISCIII) Sleep Unit Pneumology Department Vall d'Hebron Institut de Recerca (VHIR) and Vall d'Hebron University Hospital Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Valladares","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Instituto de Salud Carlos III (ISCIII) Endocrinology Department Diabetes and Metabolism Research Unit Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas Asociadas (CIBERDEM) Instituto de Salud Carlos III (ISCIII) Endocrinology Department Diabetes and Metabolism Research Unit Universitat Aut\u00f2noma de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Sim\u00f3","sequence":"additional","affiliation":[{"name":"CIBER de Diabetes y Enfermedades Metab\u00f3licas 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