{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:42:12Z","timestamp":1787013732718,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"AMDeC the Starr Foundation"},{"name":"NIH T32","award":["UL1RR0023568"],"award-info":[{"award-number":["UL1RR0023568"]}]},{"name":"CTSA","award":["UL1RR024156"],"award-info":[{"award-number":["UL1RR024156"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Elevated levels of alanine aminotransferase (\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      ) are associated with obesity and are often a consequence of non\u2010alcoholic fatty liver disease (\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      ). The aim of the present study was to assess the relationship between\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      and risk factors for adiposity\u2010related co\u2010morbidities in a diverse population of middle school children.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We measured height, weight, body fatness (bioelectrical impedance), waist circumference, insulin sensitivity, phase 1 insulin release (acute insulin response following intravenous glucose), beta\u2010cell function (acute insulin response corrected for insulin sensitivity),\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      , lipid profiles, and circulating concentrations of interleukin\u20106 (\n                      <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\n                      \u20106),\n                      <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>\n                      \u2010reactive protein, adiponectin, and tumor necrosis factor\u2010\u03b1 (\n                      <jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content>\n                      \u2010\u03b1) in a multi\u2010ethnic\/racial population of 106 middle school students (aged 11\u201314 years, 45\u2009female) of varying body mass indexes (\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Alanine aminotransferase was significantly correlated with\n                      <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\n                      , % body fat, fat mass, waist circumference, fasting insulin, insulin resistance, triglycerides, and was inversely correlated with high\u2010density lipoprotein cholesterol in children, even though all values of\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      were \u201cnormal\u201d (range of 4.0\u201333.0\u2009U\/L).\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      was significantly higher in males than females even when corrected for body fatness. Significant correlations with lipids and insulin resistance persisted even when adjusted for age, gender, and body fatness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Even within the normative range,\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      levels were significantly correlated with anthropomorphic and biochemical risk factors for adiposity\u2010related co\u2010morbidities in youth. Therefore, because\n                      <jats:styled-content style=\"fixed-case\">ALT<\/jats:styled-content>\n                      is correlated with dyslipidemia, insulin resistance, and central fat distribution, it might also serve as a marker of risk for adiposity\u2010related co\u2010morbidities beyond\n                      <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.12221","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T06:55:33Z","timestamp":1412060133000},"page":"649-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Alanine transferase: An independent indicator of adiposity related comorbidity risk in 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