{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:46:20Z","timestamp":1790451980207,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,12,23]],"date-time":"2014-12-23T00:00:00Z","timestamp":1419292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Marmara University, Scientific Research Projects Unit","award":["(#SAG-C-DRP-161111-0294"],"award-info":[{"award-number":["(#SAG-C-DRP-161111-0294"]}]},{"name":"University of Turku Institute of Dentistry"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,9]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Poorly\u2010controlled glycemic status in type 2 diabetes mellitus (\n T2DM<\/jats:styled-content>\n ) is suggested to play a role in the periodontal inflammatory process by aggregating the local cytokine response. Our objectives were to profile salivary interleukin (\n IL<\/jats:styled-content>\n )\u201017 and tumor necrosis factor (\n TNF<\/jats:styled-content>\n )\u2010\n \u03b1<\/jats:italic>\n levels in subjects with\n T2DM<\/jats:styled-content>\n and to examine their relevance for the periodontal health status and glycemic control levels.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Unstimulated whole saliva samples, together with full\u2010mouth periodontal recordings (plaque index [\n PI<\/jats:styled-content>\n ], bleeding on probing [\n BOP<\/jats:styled-content>\n %], gingival index [\n GI<\/jats:styled-content>\n ], probing pocket depth [\n PPD<\/jats:styled-content>\n ], and clinical attachment level [\n CAL<\/jats:styled-content>\n ]), were collected from 123 subjects with\n T2DM<\/jats:styled-content>\n . Additionally, demographic and general health parameters, including fasting blood glucose, glycated hemoglobin (\n HbA1c<\/jats:styled-content>\n ), were collected. Salivary\n IL<\/jats:styled-content>\n \u201017 and\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n concentrations were analyzed using the\n L<\/jats:styled-content>\n uminex\u00ae\u2010x\n MAP<\/jats:styled-content>\n \u2122 technique.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Subjects with poorly\u2010controlled\n T2DM<\/jats:styled-content>\n (\n HbA1c<\/jats:styled-content>\n \u2009\u2265\u20097) had elevated serum triglyceride (\n P<\/jats:italic>\n \u2009<\u20090.001) concentration as well as elevated scores of\n BOP<\/jats:styled-content>\n % (\n P<\/jats:italic>\n \u2009=\u20090.014),\n PI<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.048),\n GI<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.033), and\n CAL<\/jats:styled-content>\n (\n P<\/jats:italic>\n \u2009=\u20090.003) in comparison to those of well\u2010controlled\n T2DM<\/jats:styled-content>\n (\n HbA1c<\/jats:styled-content>\n \u2009<\u20097). When the subjects with detectable salivary\n IL<\/jats:styled-content>\n \u201017 were categorized in tertiles, the scores of\n PPD<\/jats:styled-content>\n and\n BOP<\/jats:styled-content>\n %, and salivary\n TNF<\/jats:styled-content>\n \u2010\n \u03b1<\/jats:italic>\n concentrations were significantly elevated in the highest (\n P<\/jats:italic>\n \u2009=\u20090.007,\n P<\/jats:italic>\n \u2009=\u20090.002 and\n P<\/jats:italic>\n \u2009<\u20090.001, respectively) and middle (\n P<\/jats:italic>\n \u2009=\u20090.052,\n P<\/jats:italic>\n \u2009=\u20090.022, and\n P<\/jats:italic>\n \u2009=\u20090.003, respectively) tertiles compared to subjects with non\u2010detectable salivary\n IL<\/jats:styled-content>\n \u201017. The adjusted association between\n PPD<\/jats:styled-content>\n measurements and salivary\n IL<\/jats:styled-content>\n \u201017 concentrations was significant (\n P<\/jats:italic>\n \u2009=\u20090.008).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Poorly\u2010controlled glycemic status relates to the severity of periodontal disease in\n T2DM<\/jats:styled-content>\n . The association between\n PPD<\/jats:styled-content>\n and\n IL<\/jats:styled-content>\n \u201017 in saliva, however, is independent from the effect of glycemic status.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/1753-0407.12228","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T07:30:08Z","timestamp":1413617408000},"page":"681-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Salivary interleukin\u201017 and tumor necrosis factor\u2010\n \u03b1<\/i>\n in relation to periodontitis and glycemic status in type 2 diabetes mellitus"],"prefix":"10.1111","volume":"7","author":[{"given":"Ulvi Kahraman","family":"G\u00fcrsoy","sequence":"first","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Yildiz \u00c7iftlikli","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Marmara Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eija","family":"K\u00f6n\u00f6nen","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mervi","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Institute of Dentistry University of Turku Turku Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ba\u015fak","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry University of Marmara Istanbul 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