{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T18:26:26Z","timestamp":1784226386993,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,3,4]],"date-time":"2015-03-04T00:00:00Z","timestamp":1425427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Foundation of China","award":["30971077"],"award-info":[{"award-number":["30971077"]}]},{"name":"Foundation of China","award":["81170784"],"award-info":[{"award-number":["81170784"]}]},{"name":"Ministry of Science & Technology Innovation Fund","award":["2011YQ030114"],"award-info":[{"award-number":["2011YQ030114"]}]},{"DOI":"10.13039\/501100014137","name":"Shanghai Shenkang Hospital Development Center","doi-asserted-by":"crossref","award":["Shdc12007309"],"award-info":[{"award-number":["Shdc12007309"]}],"id":[{"id":"10.13039\/501100014137","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Innovative Research Team of Shanghai Municipal Education Commission"},{"name":"Sector Funds of Ministry of Health","award":["201002002"],"award-info":[{"award-number":["201002002"]}]},{"DOI":"10.13039\/501100013279","name":"National Key New Drug Creation and Manufacturing Program of Ministry of Science and Technology","doi-asserted-by":"crossref","award":["2012ZX09303006-001"],"award-info":[{"award-number":["2012ZX09303006-001"]}],"id":[{"id":"10.13039\/501100013279","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fund of Shanghai Municipal Health Bureau","award":["2012-244"],"award-info":[{"award-number":["2012-244"]}]},{"name":"COFCO"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Few studies have focused on postprandial incretin responses to different carbohydrate meals. Therefore, we designed a study to compare the different effects of two carbohydrates (75\u2009g oral glucose, a monosaccharide and 100\u2009g standard noodle, a polysaccharide, with 75\u2009g carbohydrates equivalently) on postprandial glucose, insulin and incretin responses in different glucose tolerance groups.<\/jats:p><\/jats:sec>Methods<\/jats:title>This study was an open\u2010label, randomized, two\u2010way crossover clinical trial. 240 participants were assigned to take two carbohydrates in a randomized order separated by a washout period of 5\u20137 days. The plasma glucose, insulin, c\u2010peptide, glucagon and active glucagon\u2010like peptide\u20101 (AGLP<\/jats:styled-content>\u20101) were measured. The incremental area under curve above baseline from 0 to 120\u2009min of insulin (iAUC0<\/jats:sub><\/jats:styled-content>\u2013120\u2009min\u2010<\/jats:sub>INS<\/jats:styled-content>) and AGLP<\/jats:styled-content>\u20101(iAUC0<\/jats:sub><\/jats:styled-content>\u2013120\u2009min\u2010<\/jats:sub>AGLP<\/jats:styled-content>\u20101) was calculated.<\/jats:p><\/jats:sec>Results<\/jats:title>Compared with standard noodles, the plasma glucose and insulin after consumption of oral glucose were higher at 30\u2009min (both P<\/jats:italic>\u2009<\u20090.001) and 60\u2009min (both P<\/jats:italic>\u2009<\u20090.001), while lower at 180\u2009min (both P<\/jats:italic>\u2009<\u20090.001), but no differences were found at 120\u2009min. The glucagon at 180\u2009min was higher after consumption of oral glucose (P<\/jats:italic>\u2009=\u20090.010). The AGLP<\/jats:styled-content>\u20101 response to oral glucose was higher at 30\u2009min (P<\/jats:italic>\u2009<\u20090.001), 60\u2009min (P<\/jats:italic>\u2009<\u20090.001) and 120\u2009min (P<\/jats:italic>\u2009=\u20090.022), but lower at 180\u2009min (P<\/jats:italic>\u2009=\u20090.027). In normal glucose tolerance (NGT<\/jats:styled-content>), oral glucose elicited a higher insulin response to the corresponding AGLP<\/jats:styled-content>\u20101 (P<\/jats:italic>\u2009<\u20090.001), which was represented by iAUC0<\/jats:sub><\/jats:styled-content>\u2013120\u2009min<\/jats:sub>\u2010INS<\/jats:styled-content> \/iAUC0<\/jats:sub><\/jats:styled-content>\u2013120\u2009min\u2010<\/jats:sub>AGLP<\/jats:styled-content>\u20101, while in type 2 diabetes mellitus (T2DM<\/jats:styled-content>), standard noodles did (P<\/jats:italic>\u2009=\u20090.001).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Monosaccharide potentiated more rapid and higher glycemic and insulin responses. Oral glucose of liquid state would elicit a more potent release of AGLP<\/jats:styled-content>\u20101. The incretin effect was amplified after consumption of standard noodles in T2DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12245","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T09:26:21Z","timestamp":1415957181000},"page":"820-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Postprandial glucose, insulin and incretin responses to different carbohydrate tolerance tests"],"prefix":"10.1111","volume":"7","author":[{"given":"Yuying","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai Clinical Center for Endocrine and Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry Division of Endocrinology of E\u2010Institutes of Shanghai Rui\u2010jin Hospital Shanghai Jiao\u2010Tong University School of Medicine Shanghai 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