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A search of published epidemiological, clinical, or preclinical trial literature was performed using the key words \u201cdiabetes\u201d, \u201cdiabetic cystopathy\u201d, \u201cdiabetic bladder dysfunction\u201d, \u201cdiabetic lower urinary tract dysfunction\u201d, \u201cdiabetic detrusor instability\u201d. The classic symptoms of diabetic cystopathy are decreased bladder sensation, increased bladder capacity, and impaired bladder emptying with resultant increased post\u2010void residual volume. However, recent clinical evidence indicates a presence of storage symptoms, such as overactive bladder symptoms. The pathophysiology of diabetic cystopathy is multifactorial, including disturbances of the detrusor, neuron, urothelium, and urethra. Hyperglycemia, oxidative stress, and polyuria play important roles in inducing voiding dysfunction in diabetic individuals. Treatment choice depends on clinical symptoms and urodynamic abnormalities. Urodynamic evaluation is the cornerstone of diagnosis and determines management strategies. Diabetes mellitus could cause a variety of lower urinary tract symptoms, leading to diabetic cystopathy with broadly varied estimates of the prevalence rates. The exact prevalence and pathogenesis of diabetic cystopathy remains to be further investigated and studied in multicenter, large\u2010scaled, or randomized basic and clinical trials, and a validated and standardized workup needs to be made, improving diabetic cystopathy management in clinical practice. Further studies involving only female diabetics are recommended.<\/jats:p>","DOI":"10.1111\/1753-0407.12272","type":"journal-article","created":{"date-parts":[[2015,1,26]],"date-time":"2015-01-26T02:40:37Z","timestamp":1422240037000},"page":"442-447","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":115,"title":["Diabetic cystopathy: A review \u7efc\u8ff0\uff1a\u7cd6\u5c3f\u75c5\u6027\u8180\u80f1\u75c5"],"prefix":"10.1111","volume":"7","author":[{"given":"Zhengyong","family":"Yuan","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism West China Hospital, Sichuan University Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxiao","family":"He","sequence":"additional","affiliation":[{"name":"Department of Urology Dujiangyan Medical Center Dujiangyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"National Diabetes Fact Sheet: National Estimates and General Information on Diabetes and Prediabetes in the United States","author":"Centers for Disease Control and Prevention","year":"2011"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.168118"},{"key":"e_1_2_9_4_1","article-title":"Direct medical costs of diabetes mellitus in China: Annual cost of illness and long\u2010term projections using a validated diabetes model","author":"Palmer JL","year":"2012","journal-title":"Res Abstr"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2625"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1935.00160190020003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.1990.tb03525.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.177"},{"key":"e_1_2_9_9_1","first-page":"291","article-title":"Diabetic cystopathy. 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