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The incidence of NODAT<\/jats:styled-content> 3, 6, 9, 12, 36, and 60 months after transplantation was 44.24%, 25.59%, 23.08%, 25.17%, 17.86%, and 18.18%, respectively. Multifactor analysis indicated that preoperative fasting plasma glucose (FPG<\/jats:styled-content>) levels and donor liver steatosis were independent risk factors for NODAT<\/jats:styled-content>, whereas administration of an interleukin\u20102 receptor (IL\u20102R<\/jats:styled-content>) antagonist reduced the risk of NODAT<\/jats:styled-content>. Compared with the no NODAT<\/jats:styled-content> group (N<\/jats:styled-content>\u2010NODAT<\/jats:styled-content>), the NODAT<\/jats:styled-content> group had a higher rate of sepsis and chronic renal insufficiency. Mean survival was significantly longer in the N<\/jats:styled-content>\u2010NODAT<\/jats:styled-content> than NODAT<\/jats:styled-content> group. Cox regression analysis showed that pre\u2010 and\/or postoperative FPG<\/jats:styled-content> levels, tumor recurrence or metastasis, and renal insufficiency after liver transplantation were independent risk factors of mortality. Pulmonary infection or multisystem failure were specific causes of death in the NODAT<\/jats:styled-content> group, whereas patients in both groups died primarily from tumor relapse or metastasis.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Preoperative FPG<\/jats:styled-content> levels and donor liver steatosis were independent risk factors for NODAT<\/jats:styled-content>, whereas administration of an IL\u20102R<\/jats:styled-content> antagonist reduced the risk of NODAT<\/jats:styled-content>. Patients with NODAT<\/jats:styled-content> had reduced survival and an increased incidence of sepsis and chronic renal insufficiency. Significant causes of death in the NODAT<\/jats:styled-content> group were pulmonary infection and multisystem failure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12275","type":"journal-article","created":{"date-parts":[[2015,2,13]],"date-time":"2015-02-13T06:08:23Z","timestamp":1423807703000},"page":"881-890","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["New\u2010onset diabetes after liver transplantation and its impact on complications and patient survival"],"prefix":"10.1111","volume":"7","author":[{"given":"Chaoyang","family":"Lv","sequence":"first","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianying","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"},{"name":"Department of Endocrinology and Metabolism Hainan Provincial Nong Ken Hospital Hainan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengjuan","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiman","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunmei","family":"He","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gao","sequence":"additional","affiliation":[{"name":"Center of Clinical Epidemiology and Evidence\u2010based Medicine Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Zhongshan Hospital Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1267541"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0012.2011.01483.x"},{"key":"e_1_2_7_4_1","unstructured":"China Liver Transplant Registry.Annual scientific report of Chinese liver transplant in 2012.2013. 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