{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:35:56Z","timestamp":1790062556715,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,18]],"date-time":"2015-05-18T00:00:00Z","timestamp":1431907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81170751"],"award-info":[{"award-number":["81170751"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81370954"],"award-info":[{"award-number":["81370954"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81200294"],"award-info":[{"award-number":["81200294"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Cross\u2010sectional studies have reported a close association between serum lipopolysaccharide\u2010binding protein (LBP<\/jats:styled-content>) and many metabolic disorders. However, no longitudinal study has explored the relationship between LBP<\/jats:styled-content> and type 2 diabetes mellitus (T2DM<\/jats:styled-content>). The aim of the present study was to investigate the association between serum LBP<\/jats:styled-content> levels and the risk of developing T2DM<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>A 5\u2010year nested case\u2010control study of 3510 individuals was performed as part of the E<\/jats:styled-content>nvironment, I<\/jats:styled-content>nflammation and M<\/jats:styled-content>etabolic D<\/jats:styled-content>iseases S<\/jats:styled-content>tudy (EIMDS<\/jats:styled-content>). Clinical data were collected at baseline. Serum levels of LBP<\/jats:styled-content> and other biochemical factors, such as insulin and high\u2010sensitivity C<\/jats:styled-content>\u2010reactive protein, were detected 5 years later. Subjects were diagnosed as having T2DM<\/jats:styled-content> on the basis of results of an oral glucose tolerance test (OGTT<\/jats:styled-content>) and 1998 W<\/jats:styled-content>orld H<\/jats:styled-content>ealth O<\/jats:styled-content>rganization criteria. Controls were randomly selected to match cases according to age, gender, and body mass index (BMI<\/jats:styled-content>) in a 1:1 ratio. Odds ratios (OR<\/jats:styled-content>) for T2DM<\/jats:styled-content> were calculated using conditional logistic regression analysis.<\/jats:p><\/jats:sec>Results<\/jats:title>Over a 5\u2010year follow\u2010up period, 255 subjects developed T2DM<\/jats:styled-content>. There was no significant difference in serum LBP<\/jats:styled-content> levels between the T2DM<\/jats:styled-content> and control groups at baseline (19.78\u2009\u00b1\u20096.40 versus<\/jats:italic> 20.53\u2009\u00b1\u20096.99\u2009\u03bc<\/jats:italic>g\/mL; P<\/jats:italic>\u2009=\u20090.207). Subjects were divided into three groups based on tertiles of LBP<\/jats:styled-content> concentrations (n<\/jats:italic>\u2009=\u2009170 in each group; T1\u2009=\u20091.31\u201317.16\u2009\u03bc<\/jats:italic>g\/mL LBP<\/jats:styled-content>; T2\u2009=\u200917.21\u201322.37\u2009\u03bc<\/jats:italic>g\/mL LBP<\/jats:styled-content>; T<\/jats:styled-content>3\u2009=\u200922.49\u201340.08\u2009\u03bc<\/jats:italic>g\/mL LBP<\/jats:styled-content>). There was no significant association between the risk of developing T2DM<\/jats:styled-content> and any of the LBP<\/jats:styled-content> tertiles in either a simple model or after adjusting for general status and biochemical factors.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>After matching for gender, age, and BMI<\/jats:styled-content>, LBP<\/jats:styled-content> does not improve prediction of the development of T2DM<\/jats:styled-content> independently.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12281","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T13:35:35Z","timestamp":1425648935000},"page":"214-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lipopolysaccharide\u2010binding protein cannot independently predict type 2 diabetes mellitus: A nested case\u2010control study"],"prefix":"10.1111","volume":"8","author":[{"given":"Huang","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The First Affiliated Hospital of Chongqing Medical University Chongqing 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