{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:21:59Z","timestamp":1765887719057,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,7,21]],"date-time":"2015-07-21T00:00:00Z","timestamp":1437436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"crossref","award":["20062160"],"award-info":[{"award-number":["20062160"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Financial Support for Investigators in University of Liaoning Provincial Department of Education","award":["2008175"],"award-info":[{"award-number":["2008175"]}]},{"name":"National Eleventh Five Year Project","award":["2006BAI02B08"],"award-info":[{"award-number":["2006BAI02B08"]}]},{"name":"Research Fund for the Doctoral Program of Higher Education, China","award":["20132105120012"],"award-info":[{"award-number":["20132105120012"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2016,1]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>To study the relationship between positivity for hepatitis B<\/jats:styled-content> surface antibody (HBsAb<\/jats:styled-content>) and the risk of diabetes mellitus in the retired C<\/jats:styled-content>hinese population.<\/jats:p><\/jats:sec>Methods<\/jats:title>A cross\u2010sectional analysis was conducted in 900 retired C<\/jats:styled-content>hinese workers attending a health check\u2010up program. HBsAb<\/jats:styled-content>, hepatitis B<\/jats:styled-content> surface antigen, oral glucose tolerance test (OGTT<\/jats:styled-content>), fasting plasma glucose (FBG), 2\u2010h plasma glucose 2hBG, and insulin levels were collected.<\/jats:p><\/jats:sec>Results<\/jats:title>Participants positive for HBsAb<\/jats:styled-content> were younger, with lower blood pressure, lower FBG and 2hBG serum uric acid, and glutamic pyruvic transaminase than those who were HbsAb<\/jats:styled-content> negative. There were 306 subjects with impaired glucose tolerance and 121 with type 2 diabetes (T2D<\/jats:styled-content>) in the present cohort. Using C<\/jats:styled-content>hi\u2010squared analysis to assess the risk of diabetes, women positive for HBsAb<\/jats:styled-content> had a lower prevalence of T2D<\/jats:styled-content> than those negative for HBsAb<\/jats:styled-content> (15.7% vs 26.5%, respectively; P<\/jats:italic>\u2009<\u20090.01). Multivariate analysis revealed family history of diabetes, age, and waist circumference were independently associated with a higher prevalence of diabetes, and that HBsAb positivity was independently associated with a lower prevalence of diabetes (odds ratio 0.579; 95% confidence interval 0.388\u20130.918) when adjusted for sex, family history of hypertension and dyslipidemia, and body mass index.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>An HBsAb<\/jats:styled-content>\u2010positive status is associated with a low rate of diabetes and better metabolic status. A prospective study of patients with known vaccination records is needed to investigate whether hepatitis B<\/jats:styled-content> virus vaccination could protect against the development of diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12317","type":"journal-article","created":{"date-parts":[[2015,5,28]],"date-time":"2015-05-28T06:13:23Z","timestamp":1432793603000},"page":"158-161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Positive hepatitis B<\/scp> surface antibody is associated with reduced risk of diabetes mellitus in retired female C<\/scp>hinese workers"],"prefix":"10.1111","volume":"8","author":[{"given":"Ming","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microecology School of Basic Medical Science Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China"},{"name":"Department of Endocrinology and Metabolism Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufeng","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benli","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Endocrinology The Second Affiliated Hospital of Dalian Medical University Dalian China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20920"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2007.02.014"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2007.01630.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.01038.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.11.022"},{"key":"e_1_2_8_7_1","first-page":"1709","article-title":"Use of hepatitis B vaccination for adults with diabetes mellitus: Recommendations of the Advisory Committee on Immunization Practices (ACIP)","volume":"60","author":"Centers for Disease Control and Prevention","year":"2011","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-0759"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"volume-title":"Definition, Diagnosis and Classification of Diabetes Mellitus and Its Complications. 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