{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:56:24Z","timestamp":1792601784668,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,4]],"date-time":"2015-11-04T00:00:00Z","timestamp":1446595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:p>1969\u5e74,McCully \u9996\u6b21\u53d1\u73b0\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5373\u4f7f\u8f7b\u5ea6\u5347\u9ad8\u4e5f\u53ef\u52a0\u901f\u52a8\u8109\u7ca5\u6837\u786c\u5316\u7684\u53d1\u5c55,\u7531\u6b64\u63d0\u51fa\u201c\u540c\u578b\u534a\u80f1\u6c28\u9178\u2010\u52a8\u8109\u7ca5\u6837\u786c\u5316\u5b66\u8bf4\u201d<jats:sup>1<\/jats:sup>\u3002\u63a5\u4e0b\u6765\u7684\u4e00\u4e9b\u524d\u77bb\u6027\u961f\u5217\u7814\u7a76\u63d0\u51fa,\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u6bcf\u964d\u4f4e3 \u00b5mol\/L\u53ef\u4ee5\u4f7f\u8111\u5352\u4e2d\u98ce\u9669\u4e0b\u964d24%<jats:sup>2<\/jats:sup>\u3002\u7136\u800c,\u8003\u5bdf\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u5bf9\u8111\u5352\u4e2d\u5f71\u54cd\u7684\u4e00\u4e9b\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u5e76\u672a\u89c2\u5bdf\u5230\u660e\u786e\u7684\u7ed3\u679c<jats:sup>3<\/jats:sup>\u3002\u9700\u8981\u6ce8\u610f\u7684\u662f,\u6d41\u884c\u75c5\u5b66\u7814\u7a76\u4e0e\u4e34\u5e8a\u8bd5\u9a8c\u5b58\u5728\u8bf8\u591a\u91cd\u8981\u7684\u4e0d\u540c\u4e4b\u5904\u3002\u4e00\u822c\u961f\u5217\u7814\u7a76\u591a\u5173\u6ce8\u76f8\u5bf9\u5065\u5eb7\u4eba\u7fa4,\u800c\u5927\u591a\u6570\u4e34\u5e8a\u7814\u7a76\u5165\u7ec4\u7684\u5219\u662f\u60a3\u6709\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u7684\u53d7\u8bd5\u8005;\u6b64\u5916,\u5f88\u591a\u4e34\u5e8a\u7814\u7a76\u5165\u7ec4\u7684\u662f\u672c\u8eab\u53f6\u9178\u6444\u5165\u8f83\u591a\u6216\u5df2\u7ecf\u5728\u98df\u7269\u4e2d\u5f3a\u5316\u8865\u5145\u53f6\u9178\u7684\u4eba\u7fa4<jats:sup>3<\/jats:sup>,\u56e0\u800c\u7f3a\u4e4f\u8db3\u591f\u7684\u6548\u80fd\u68c0\u6d4b\u51fa\u8865\u5145\u53f6\u9178\u7684\u660e\u663e\u7597\u6548\u3002\u56e0\u6b64,\u5728\u8840\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5347\u9ad8\u4e14\u672a\u7ecf\u98df\u7269\u5f3a\u5316\u8865\u5145\u53f6\u9178\u7684\u4eba\u7fa4\u4e2d\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u662f\u5426\u53ef\u4ee5\u83b7\u76ca\u76ee\u524d\u5c1a\u4e0d\u660e\u786e\u3002\u9274\u522b\u51fa\u53ef\u4ee5\u663e\u8457\u53d7\u76ca\u4e8e\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u7684\u4eba\u7fa4\u4e0d\u4ec5\u53ef\u4ee5\u8fdb\u4e00\u6b65\u89e3\u91ca\u75be\u75c5\u7684\u53d1\u75c5\u673a\u7406,\u540c\u65f6\u5177\u6709\u975e\u5e38\u91cd\u8981\u7684\u4e34\u5e8a\u548c\u516c\u5171\u536b\u751f\u4ef7\u503c\u3002<\/jats:p><jats:p>\u65e2\u5f80\u7814\u7a76\u8868\u660e\u9ad8\u8840\u538b\u662f\u8111\u5352\u4e2d\u7684\u91cd\u8981\u53ef\u5e72\u9884\u5371\u9669\u56e0\u7d20<jats:sup>4<\/jats:sup>\u3002\u66f4\u4e3a\u91cd\u8981\u7684\u662f,\u9ad8\u8840\u538b\u548c\u540c\u578b\u534a\u80f1\u6c28\u9178\u5347\u9ad8\u5bf9\u8111\u5352\u4e2d\u98ce\u9669\u5347\u9ad8\u663e\u793a\u51fa\u4e86\u4ea4\u4e92\u6548\u5e94\u3002\u4e0e\u65e0\u9ad8\u8840\u538b\u4e14\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u6b63\u5e38\u4eba\u7fa4\u76f8\u6bd4,\u540c\u65f6\u6709\u9ad8\u8840\u538b\u548c\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5347\u9ad8(\u2265 10 \u00b5mol\/L)\u7684\u4eba\u7fa4(\u6211\u4eec\u5c06\u8be5\u4eba\u7fa4\u5b9a\u4e49\u4e3a\u201cH\u578b\u9ad8\u8840\u538b\u201d)\u7684\u8111\u5352\u4e2d\u98ce\u9669\u663e\u8457\u5347\u9ad8(\u7537\u6027:OR,12,95% CI:6\u201023;\u5973\u6027:OR,17,95% CI:10\u201029)<jats:sup>5<\/jats:sup>\u3002\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5347\u9ad8\u591a\u6e90\u4e8e\u53f6\u9178\u6444\u5165\u4e0d\u8db3,\u6216\u53f6\u9178\u53ca\u540c\u578b\u534a\u80f1\u6c28\u9178\u4ee3\u8c22\u8fc7\u7a0b\u4e2d\u5173\u952e\u9176\u7684\u57fa\u56e0\u7f3a\u9677<jats:sup>6,7<\/jats:sup>\u3002\u6709\u7814\u7a76\u8868\u660e,\u4f7f\u7528\u964d\u538b\u836f,\u5c24\u5176\u662f\u8840\u7ba1\u7d27\u5f20\u7d20\u8f6c\u5316\u9176\u6291\u5236\u5242\u4e0e\u53f6\u9178\u8054\u5408,\u53ef\u4ee5\u6709\u6548\u63a7\u5236H\u578b\u9ad8\u8840\u538b\u7684\u98ce\u9669<jats:sup>8,9<\/jats:sup>\u3002\u4f8b\u5982,Albert\u7b49\u7814\u7a76\u53d1\u73b0ACEI\u4e0e\u8865\u5145\u53f6\u9178\u7597\u6cd5\u5728\u964d\u4f4e\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u65b9\u9762\u5177\u6709\u663e\u8457\u7684\u4ea4\u4e92\u4f5c\u7528(<jats:italic>P<\/jats:italic> = 0.03)<jats:sup>9<\/jats:sup>\u3002<\/jats:p><jats:p>\u540c\u578b\u534a\u80f1\u6c28\u9178\u5347\u9ad8\u5bf9\u8840\u7ba1\u6709\u591a\u91cd\u4e0d\u826f\u6548\u5e94,\u5305\u62ec\u635f\u4f24\u5185\u76ae\u7ec6\u80de\u3001\u4fc3\u8fdb\u6c27\u5316\u5e94\u6fc0\u53ca\u6539\u53d8DNA\u7532\u57fa\u5316\u7b49<jats:sup>10<\/jats:sup>\u3002\u540c\u65f6,\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5347\u9ad8\u662f\u53f6\u9178\u7f3a\u4e4f\u7684\u91cd\u8981\u6307\u6807;\u9664\u4e86\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u5916,\u53f6\u9178\u5177\u6709\u76f4\u63a5\u6297\u6c27\u5316\u53ca\u5185\u76ae\u7ec6\u80de\u4fdd\u62a4\u6548\u5e94(\u4f5c\u7528\u4e8e\u5185\u76ae\u7ec6\u80de\u4e00\u6c27\u5316\u6c2e\u5408\u6210\u9176)<jats:sup>11<\/jats:sup>\u3002<\/jats:p><jats:p>\u6211\u4eec\u524d\u671f\u4e00\u9879meta\u5206\u6790\u8868\u660e,\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u7684\u6cbb\u7597(\u4e3b\u8981\u662f\u8865\u5145\u53f6\u9178)\u80fd\u591f\u663e\u8457\u964d\u4f4e\u8111\u5352\u4e2d\u98ce\u9669<jats:sup>3<\/jats:sup>;\u53e6\u4e00\u9879meta\u5206\u6790\u5219\u53d1\u73b0\u8865\u5145\u53f6\u9178\u53ef\u4ee5\u663e\u8457\u964d\u4f4e\u6162\u6027\u80be\u810f\u75c5\u60a3\u8005\u7684\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u98ce\u9669<jats:sup>12<\/jats:sup>;\u540c\u65f6,\u8865\u5145\u53f6\u9178\u53ef\u4ee5\u964d\u4f4e\u9888\u52a8\u8109\u5185\u819c\u4e2d\u819c\u539a\u5ea6\u7684\u8fdb\u5c55(CIMT;\u52a0\u6743\u5e73\u5747\u5dee\u5f02:\u20100.04 mm;95%\u53ef\u4fe1\u533a\u95f4:\u20100.07\u81f3\u20100.02;<jats:italic>P<\/jats:italic> &lt; 0.001),\u4e14\u540c\u578b\u534a\u80f1\u6c28\u9178\u7684\u964d\u4f4e\u7a0b\u5ea6\u4e0eCIMT\u7684\u964d\u4f4e\u5448\u73b0\u5242\u91cf\u6548\u5e94\u5173\u7cfb(<jats:italic>P<\/jats:italic> &lt; 0.001)<jats:sup>13<\/jats:sup>\u3002\u7136\u800c,\u5c3d\u7ba1\u6709\u8fd9\u4e9b\u4ee4\u4eba\u5174\u594b\u7684\u7ed3\u679c,\u5728\u4e2d\u56fd\u8111\u5352\u4e2d\u4e00\u7ea7\u9884\u9632\u7814\u7a76(China Stroke Primary Trial,CSPPT;ClinicalTrials.gov ID NCT00794885)<jats:sup>8<\/jats:sup>\u4e4b\u524d,\u53ea\u6709Suppl\u00e9mentation en Folates et Omega\u20103(SU.FOL.OM3)\u7814\u7a76\u548cHeart Outcomes Prevention Evaluation(HOPE)2\u7814\u7a76<jats:sup>14,15<\/jats:sup>\u63d0\u793a\u8865\u5145\u53f6\u9178\u5bf9\u964d\u4f4e\u8111\u5352\u4e2d\u6709\u79ef\u6781\u4f5c\u7528,\u5e76\u4e14\u8111\u5352\u4e2d\u7684\u53d1\u751f\u5728\u8fd9\u4e24\u9879\u7814\u7a76\u4e2d\u4ec5\u4e3a\u6b21\u8981\u7ec8\u70b9\u3002<\/jats:p><jats:p>\u4ece2008\u5e745\u670819\u65e5\u81f32013\u5e748\u670824\u65e5,\u6211\u4eec\u5728\u4e2d\u56fd\u9ad8\u8840\u538b\u4eba\u7fa4\u4e2d\u7ec4\u7ec7\u8fdb\u884c\u4e86CSPPT\u7814\u7a76\u3002\u6211\u4eec\u9884\u671f\u4e2d\u56fd\u9ad8\u8840\u538b\u4eba\u7fa4\u53ef\u4ee5\u6700\u5927\u7a0b\u5ea6\u53d7\u76ca\u4e8e\u964d\u538b\u548c\u8865\u5145\u53f6\u9178\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u7684\u540c\u65f6\u6cbb\u7597\u3002\u4e2d\u56fd\u672a\u8fdb\u884c\u98df\u7269\u5f3a\u5316\u8865\u5145\u53f6\u9178\u7684\u63aa\u65bd,\u672a\u5e7f\u6cdb\u4f7f\u7528\u53f6\u9178\u8865\u5145\u5242,\u540c\u65f6\u5177\u6709\u6781\u9ad8\u7684\u8111\u5352\u4e2d\u75be\u75c5\u8d1f\u62c5\u3002\u8111\u5352\u4e2d\u662f\u76ee\u524d\u4e2d\u56fd\u4eba\u7fa4\u7684\u9996\u4f4d\u6b7b\u56e0;\u4ece1984\u5e74\u81f32004\u5e74,\u5e74\u9f84\u6807\u5316\u7684\u7f3a\u8840\u6027\u8111\u5352\u4e2d\u7684\u53d1\u75c5\u7387\u4ecd\u4ee5\u6bcf\u5e748.7%(95% CI:4.3\u20108.9,<jats:italic>P<\/jats:italic> &lt; 0.05)\u7684\u901f\u7387\u9010\u5e74\u4e0a\u5347<jats:sup>16<\/jats:sup>\u3002\u4e2d\u56fd\u4eba\u7fa4\u540c\u65f6\u5177\u6709\u5f88\u9ad8\u7684\u9ad8\u8840\u538b\u60a3\u75c5\u7387;\u57fa\u4e8e\u4e00\u9879\u5168\u56fd\u8c03\u67e5,2009\u20102010\u5e74\u4e2d\u56fd\u9ad8\u8840\u538b\u60a3\u75c5\u7387\u4e3a29.6%,\u7537\u6027(31.2%)\u9ad8\u4e8e\u5973\u6027(28.0%)<jats:sup>17<\/jats:sup>\u3002\u975e\u5e38\u503c\u5f97\u5173\u6ce8\u7684\u662f,\u7ea675%\u7684\u9ad8\u8840\u538b\u4eba\u7fa4\u4f34\u6709\u8840\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u7684\u5347\u9ad8(H\u578b\u9ad8\u8840\u538b)<jats:sup>18<\/jats:sup>\u3002H\u578b\u9ad8\u8840\u538b\u7684\u9ad8\u53d1\u53ef\u80fd\u662f\u6211\u56fd\u9ad8\u8840\u538b\u4eba\u7fa4\u7684\u8111\u5352\u4e2d\u60a3\u75c5\u5373\u4f7f\u5728\u826f\u597d\u63a7\u5236\u8840\u538b\u540e\u4f9d\u7136\u5c45\u9ad8\u4e0d\u4e0b\u7684\u91cd\u8981\u539f\u56e0\u4e4b\u4e00\u3002<\/jats:p><jats:p>\u53ef\u4ee5\u9884\u671f,\u540c\u65f6\u5e72\u9884\u8111\u5352\u4e2d\u7684\u8fd9\u4e24\u9879\u4e3b\u8981\u5371\u9669\u56e0\u7d20(\u9ad8\u8840\u538b\u548c\u9ad8\u540c\u578b\u534a\u80f1\u6c28\u9178\u8840\u75c7)\u5c06\u6bd4\u5355\u72ec\u5e72\u9884\u5176\u4e2d\u4e00\u9879\u66f4\u52a0\u6709\u6548\u3002CSPPT\u7814\u7a76\u5e0c\u671b\u8bc1\u5b9e\u4e0a\u8ff0\u5047\u8bbe,\u5176\u4e3b\u8981\u7814\u7a76\u76ee\u7684\u662f\u8003\u5bdf\u4e0e\u5355\u72ec\u4f7f\u7528\u4f9d\u90a3\u666e\u5229\u7247\u76f8\u6bd4,\u4f9d\u90a3\u666e\u5229\u53f6\u9178\u7247(\u5355\u7247\u590d\u65b9\u5236\u5242)\u6cbb\u7597\u662f\u5426\u53ef\u4ee5\u8fdb\u4e00\u6b65\u6709\u6548\u964d\u4f4e\u4e0d\u4f34\u8111\u5352\u4e2d\u6216\u5fc3\u808c\u6897\u6b7b\u75c5\u53f2\u7684\u539f\u53d1\u6027\u9ad8\u8840\u538b\u60a3\u8005\u7684\u8111\u5352\u4e2d\u53d1\u751f\u98ce\u9669\u3002<\/jats:p><jats:p>CSPPT\u7814\u7a76\u603b\u5171\u7eb3\u516520702\u4f8b\u9ad8\u8840\u538b\u60a3\u8005,\u662f\u76ee\u524d\u8bc4\u4f30\u964d\u538b\u836f\u7269\u5408\u5e76\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u6cbb\u7597\u5bf9\u8111\u5352\u4e2d\u4e00\u7ea7\u9884\u9632\u7597\u6548\u7684\u6837\u672c\u91cf\u6700\u5927\u7684\u4e00\u9879\u968f\u673a\u3001\u5bf9\u7167\u4e34\u5e8a\u8bd5\u9a8c\u3002\u7814\u7a76\u7ed3\u679c\u53d1\u73b0,\u5728\u4e0d\u4f34\u8111\u5352\u4e2d\u6216\u5fc3\u808c\u6897\u6b7b\u75c5\u53f2\u7684\u9ad8\u8840\u538b\u60a3\u8005\u4e2d,\u4e0e\u5355\u7528\u4f9d\u90a3\u666e\u5229\u6cbb\u7597\u76f8\u6bd4,\u4f9d\u90a3\u666e\u5229\u8054\u5408\u53f6\u9178\u6cbb\u7597(\u53f6\u91780.8 mg\/\u5929)\u80fd\u591f\u663e\u8457\u964d\u4f4e\u8111\u5352\u4e2d\u7684\u53d1\u75c5\u7387\u8fbe21%(HR,0.79;95% CI:0.68\u20100.93)<jats:sup>8<\/jats:sup>\u3002\u66f4\u91cd\u8981\u7684\u662f,\u6821\u6b63\u5e74\u9f84\u3001\u6027\u522b\u3001\u7814\u7a76\u4e2d\u5fc3\u3001\u57fa\u7ebf\u6536\u7f29\u538b\u3001\u8212\u5f20\u538b\u548c\u8fc7\u7a0b\u6536\u7f29\u538b\u3001\u8212\u5f20\u538b\u540e,H\u578b\u9ad8\u8840\u538b\u60a3\u8005(\u5360\u672c\u7814\u7a76\u4eba\u7fa4\u768480.3%,HR,0.78;95% CI:0.66\u20100.93)\u8f83\u975eH\u578b\u9ad8\u8840\u538b\u60a3\u8005\u83b7\u76ca\u66f4\u4e3a\u5145\u5206(HR,0.94;95% CI:0.62\u20101.42)\u3002<\/jats:p><jats:p>\u8d8a\u6765\u8d8a\u591a\u7684\u8bc1\u636e\u8868\u660e,\u9ad8\u540c\u578b\u534a\u80f1\u6c28\u9178\u8840\u75c7\u548c2\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u751f\u5bc6\u5207\u76f8\u5173\u30022010\u5e74\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u7684\u60a3\u75c5\u7387\u7ea6\u4e3a11.6%(95% CI:11.3%\u201011.8%)<jats:sup>19<\/jats:sup>\u3002\u8fd1\u671f\u4e00\u9879\u5bf9\u75c5\u4f8b\u5bf9\u7167\u7814\u7a76\u7684meta\u5206\u6790\u62a5\u9053,2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u663e\u8457\u9ad8\u4e8e\u975e2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005(\u5e73\u5747\u5dee\u5f02\u4e3a0.94 \u00b5mol\/L;95% CI:0.40\u20101.48)<jats:sup>20<\/jats:sup>\u3002\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5347\u9ad8\u53ef\u80fd\u4fc3\u8fdb2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u7684\u80f0\u5c9b\u7d20\u62b5\u6297,\u589e\u52a0\u6b7b\u4ea1\u98ce\u9669<jats:sup>21<\/jats:sup>\u3002\u7136\u800c,\u5c1a\u6709\u5f88\u591a\u5173\u952e\u95ee\u9898\u6709\u5f85\u89e3\u51b3\u3002<\/jats:p><jats:p>\u9996\u5148,\u8865\u5145\u53f6\u9178\u662f\u5426\u80fd\u591f\u9884\u96322\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u751f\u6216\u53d1\u5c55?Women's Antioxidant and Folic Acid Cardiovascular Study(WAFACS)\u7814\u7a76\u53d1\u73b0,\u5728\u6709\u5fc3\u8111\u8840\u7ba1\u75be\u75c5\u75c5\u53f2\u62163\u9879\u4ee5\u4e0a\u5fc3\u8840\u7ba1\u5371\u9669\u56e0\u7d20\u768440\u5c81\u53ca\u4ee5\u4e0a\u5973\u6027,\u7ecf\u8fc77\u5e74\u7684\u6cbb\u7597,\u6bcf\u65e5\u8865\u5145\u53f6\u9178\u548c\u7ef4\u751f\u7d20B<jats:sub>6<\/jats:sub>\u3001B<jats:sub>12<\/jats:sub>\u5e76\u4e0d\u80fd\u591f\u964d\u4f4e2\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u751f\u98ce\u9669<jats:sup>22<\/jats:sup>\u3002\u7136\u800c,WAFACS\u7684\u6240\u6709\u53d7\u8bd5\u8005\u5747\u6765\u81ea\u98df\u7269\u4e2d\u5f3a\u5316\u8865\u5145\u53f6\u9178\u7684\u56fd\u5bb6\u3002\u5f3a\u5316\u53f6\u9178\u5f88\u53ef\u80fd\u964d\u4f4e\u4e86\u6700\u53ef\u80fd\u53d7\u76ca\u7684\u4eba\u7fa4\u7684\u6bd4\u4f8b,\u5373\u540c\u578b\u534a\u80f1\u6c28\u9178\u6c34\u5e73\u5347\u9ad8\u6216\u53f6\u9178\u6c34\u5e73\u8f83\u4f4e\u7684\u60a3\u8005\u6570\u91cf\u5927\u5e45\u51cf\u5c11\u3002<\/jats:p><jats:p>\u5176\u6b21,\u4e4b\u524d\u4e00\u9879meta\u5206\u6790\u8868\u660e,\u8865\u5145\u53f6\u9178\u964d\u4f4e\u540c\u578b\u534a\u80f1\u6c28\u9178\u80fd\u591f\u6709\u6548\u9884\u9632\u6162\u6027\u80be\u810f\u75c5\u60a3\u8005\u7684\u5fc3\u8840\u7ba1\u75be\u75c5\u98ce\u9669;\u7136\u800c,\u5176\u7597\u6548\u53d7\u5230\u57fa\u7ebf\u7cd6\u5c3f\u75c5\u60a3\u8005\u6bd4\u4f8b\u7684\u663e\u8457\u5f71\u54cd(<jats:italic>P<\/jats:italic> = 0.007)<jats:sup>12<\/jats:sup>\u3002\u9700\u8981\u66f4\u591a\u7684\u7814\u7a76\u53bb\u8bc4\u4f30\u57fa\u7ebf\u7a7a\u8179\u8840\u7cd6\u548c\/\u6216\u7cd6\u5316\u8840\u7ea2\u86cb\u767d\u6c34\u5e73\u5bf9\u8865\u5145\u53f6\u9178\u4e00\u7ea7\u9884\u96322\u578b\u7cd6\u5c3f\u75c5\u53ca\u8840\u7ba1\u6027\u5e76\u53d1\u75c7\u7684\u7597\u6548\u7684\u5f71\u54cd\u7a0b\u5ea6\u3002<\/jats:p><jats:p>\u603b\u4e4b,CSPPT\u7814\u7a76\u4ee5\u5176\u5927\u6837\u672c\u53ca\u72ec\u7279\u7684\u8bbe\u8ba1,\u4e3a\u8865\u5145\u53f6\u9178\u5408\u5e76\u964d\u538b\u6cbb\u7597\u5bf9\u8111\u5352\u4e2d\u4e00\u7ea7\u9884\u9632\u4f5c\u7528\u7684\u6709\u6548\u6027\u63d0\u4f9b\u4e86\u786e\u5207\u7684\u7b54\u6848\u3002\u8865\u5145\u53f6\u9178\u5408\u5e76\u964d\u538b\u6cbb\u7597\u5bf92\u578b\u7cd6\u5c3f\u75c5\u7684\u53d1\u751f\u53d1\u5c55\u53ca\u5176\u8840\u7ba1\u6027\u5e76\u53d1\u75c7\u7684\u4f5c\u7528\u5c1a\u9700\u66f4\u591a\u7684\u7814\u7a76\u6765\u8fdb\u884c\u63a2\u8ba8;\u76ee\u524d\u5c24\u5176\u7f3a\u4e4f\u5728\u672a\u5f3a\u5316\u8865\u5145\u53f6\u9178\u7684\u4eba\u7fa4\u4e2d\u7684\u76f8\u5173\u8bc1\u636e\u3002\u5982\u679c\u80fd\u591f\u9610\u660e\u8fd9\u4e9b\u5173\u7cfb\u53ca\u5176\u76f8\u5173\u7684\u673a\u5236,\u5c06\u5bf9\u4e34\u5e8a\u548c\u516c\u5171\u536b\u751f\u5b9e\u8df5\u4ea7\u751f\u5de8\u5927\u7684\u5f71\u54cd\u3002<\/jats:p>","DOI":"10.1111\/1753-0407.12333","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T19:57:49Z","timestamp":1441223869000},"page":"38-40","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["H\u2010Type hypertension, stroke and diabetes in China: Opportunities for primary prevention"],"prefix":"10.1111","volume":"8","author":[{"given":"Xianhui","family":"Qin","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division Nanfang Hospital, Southern Medical University  Guangzhou"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Huo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,4]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"111","article-title":"Vascular pathology of homocystinemia: Implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully KS","year":"1969","journal-title":"Am J Pathol."},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.325.7374.1202"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-1241.2012.02929.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7404.1419"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2010.07.013"},{"key":"e_1_2_4_7_1","first-page":"976","article-title":"Prevention of stroke relies on valid control \u201cH\u201d type hypertension","volume":"47","author":"Hu D","year":"2008","journal-title":"Chinese Journal of Internal Medicine."},{"key":"e_1_2_4_8_1","first-page":"3","article-title":"Hypertension with elevated homocysteine\u2010H type hypertension","volume":"32","author":"Zhang Y","year":"2011","journal-title":"Adv Cardiovasc Dis."},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.2274"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.17.2027"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000115161.10646.67"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/hq0102.102190"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.12.009"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2011.12.007"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c6273"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa060900"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.502807"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpu053"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e32834ac5e8"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.168118"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-14-867"},{"key":"e_1_2_4_22_1","article-title":"Novel clinical evidence of an association between homocysteine and insulin resistance in patients with hypothyroidism or subclinical hypothyroidism","volume":"10","author":"Yang N","year":"2015","journal-title":"PLoS One."},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0087"}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1753-0407.12333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1753-0407.12333","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.12333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:54:09Z","timestamp":1696233249000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.12333"}},"subtitle":["H\u578b\u9ad8\u8840\u538b,\u8111\u5352\u4e2d\u548c\u7cd6\u5c3f\u75c5:\u4e2d\u56fd\u4eba\u7fa4\u4e00\u7ea7\u9884\u9632\u7684\u673a\u9047"],"short-title":[],"issued":{"date-parts":[[2015,11,4]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1111\/1753-0407.12333"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.12333","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,4]]},"assertion":[{"value":"2015-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-08-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-11-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}