{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:36:04Z","timestamp":1761896164558},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,22]],"date-time":"2016-01-22T00:00:00Z","timestamp":1453420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the present post hoc analysis of the China Stroke Primary Prevention Trial (CSPPT) was to evaluate the effect of folic acid supplementation on the risk of new\u2010onset diabetes in hypertensive adults in China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 20 702 hypertensive adults with no history of stroke and\/or myocardial infarction (MI) were randomly assigned to receive double\u2010blind daily treatment with tablets containing either: (i) 10 mg enalapril and 0.8 mg folic acid (n = 10 348); or (ii) 10 mg enalapril alone (n = 10 354). New\u2010onset diabetes was defined as either self\u2010reported physician\u2010diagnosed diabetes or the use of glucose\u2010lowering drugs during the follow\u2010up period of the CSPPT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median treatment duration of 4.5 years, new\u2010onset diabetes occurred in 198 (2.0%) and 214 (2.1%) subjects in the enalapril\u2013folic acid and enalapril groups, respectively (hazard ratio [HR] 0.92; 95% confidence interval [CI] 0.76\u20131.12). Similar results were observed when analyses were limited to subjects with baseline fasting glucose (FG) &lt;7.0 mmol\/L (HR 0.85; 95% CI 0.62\u20131.14). Furthermore, there was no significant group difference in: (i) the risk of new\u2010onset FG \u22657.0 mmol\/L (defined as FG &lt;7.0 at baseline and \u22657.0 mmol\/L at the last visit; relative risk [RR] 1.07; 95% CI 0.96\u20131.20); or (ii) the composite of new\u2010onset diabetes or new\u2010onset FG \u22657.0 mmol\/L (RR = 1.06; 95% CI 0.95\u20131.19).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among adults with hypertension with no history of stroke and\/or MI in China, folic acid supplementation had no significant effect on the risk of new\u2010onset diabetes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12346","type":"journal-article","created":{"date-parts":[[2015,10,12]],"date-time":"2015-10-12T22:18:18Z","timestamp":1444688298000},"page":"286-294","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Effect of folic acid supplementation on risk of new\u2010onset diabetes in adults with hypertension in China: Findings from the China Stroke Primary Prevention Trial (CSPPT)"],"prefix":"10.1111","volume":"8","author":[{"given":"Xianhui","family":"Qin","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital Southern Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Peking University First Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dafang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yefeng","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Neurology Guangdong Provincial Hospital of Chinese Medicine  Guangzhou"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuli","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Neurology First Affiliated Hospital of Anhui Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital Southern Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan Fan","family":"Hou","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang 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