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Epoxyeicosatrienoic acids can be further hydrolyzed to less active diols by the enzyme soluble epoxide hydrolase (sEH). Increasing evidence suggests that inhibition of sEH increases levels of EETs, which have anti\u2010inflammatory effects and can prevent the development of hypertension, atherosclerosis, heart failure, fatty liver, and multiple organ fibrosis. Arachidonic acid is the most abundant omega\u20106 polyunsaturated fatty acid (PUFA) and shares the same set of enzymes with omega\u20103 PUFAs, such as docosahexaenoic acid and eicosapentaenoic acid. The omega\u20103 PUFAs and metabolites, such as regioisomeric epoxyeicosatetraenoic acids and epoxydocosapentaenoic acids, have been reported to have strong vasodilatory and anti\u2010inflammatory effects. Therefore, sEH may be a potential therapeutic target for metabolic disorders. In this review, we focus on our and other recent studies of the functions of sEH, including the effects of its eicosanoid products from both omega\u20103 and omega\u20106 PUFAs, in various metabolic diseases. We also discuss the possible cellular and molecular mechanisms underlying the regulation of sEH.<\/jats:p>","DOI":"10.1111\/1753-0407.12358","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T11:07:20Z","timestamp":1448968040000},"page":"305-313","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Soluble epoxide hydrolase: A potential target for metabolic diseases"],"prefix":"10.1111","volume":"8","author":[{"given":"Jinlong","family":"He","sequence":"first","affiliation":[{"name":"Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Physiology and Pathophysiology Tianjin Medical University  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunjiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Collaborative Innovation Center of Tianjin for Medical Epigenetics, Department of Physiology and Pathophysiology 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