{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:15:20Z","timestamp":1777544120775,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,30]],"date-time":"2016-05-30T00:00:00Z","timestamp":1464566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Studies from other countries indicate that utilization patterns of antidiabetic drugs change significantly after the introduction of newer classes of antidiabetic drugs (e.g. dipeptidyl peptidase\u20104 inhibitors [DPP\u20104i]). Evidence on recent trends regarding antidiabetic drug use in Taiwan is lacking, especially for times after the introduction of newer classes of drugs (e.g. DPP\u20104i). Therefore, the aim of the present study was to assess: (i) recent trends in the use and spending on antidiabetic drugs; (ii) changes in utilization patterns after introduction of newer classes of antidiabetic drugs; and (iii) factors associated with the choice of newer versus older classes of antidiabetic drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases of type 2 diabetes were derived from Taiwan's National Health Insurance Research Database. Antidiabetic drug use was measured in terms of total quantity of drug exposure and healthcare spending in each calendar year from 2008 to 2103. Multiple logistic regression analysis was used to assess factors associated with drug choice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of and healthcare spending on DPP\u20104i increased significantly from 2008 to 2013, whereas healthcare spending on sulfonylureas decreased. For monotherapy, sulfonylureas were the most common alternatives to metformin, whereas in dual and triple antidiabetic therapies, a DPP\u20104i was the most common alternative to initial regimens. The use of a DPP\u20104i was positively associated with the use of beta\u2010blockers, angiotensin II\u2010converting enzyme inhibitors and\/or angiotensin receptor blockers, and lipid\u2010lowering agents, but negatively correlated with age, hypertension, severity of diabetes complications, and the use of diuretics and calcium channel blockers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With growing spending on newer antidiabetic drugs, future research on the comparative cost\u2010effectiveness and safety of antidiabetic drugs is anticipated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12408","type":"journal-article","created":{"date-parts":[[2016,4,10]],"date-time":"2016-04-10T16:49:22Z","timestamp":1460306962000},"page":"256-266","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Recent trends in the use of antidiabetic medications from 2008 to 2013: A nation\u2010wide population\u2010based study from Taiwan"],"prefix":"10.1111","volume":"9","author":[{"given":"Huang\u2010Tz","family":"Ou","sequence":"first","affiliation":[{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences National Cheng Kung University Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacy and Pharmaceutical Sciences National Cheng Kung University Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya\u2010Ming","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, College of Medicine National Cheng Kung University Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Shang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Economics School of Social Sciences, National Cheng Kung University  Tainan Taiwan"},{"name":"Department of Family Medicine National Cheng Kung University Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,30]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization (WHO).Diabetes fact sheet.2016. 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