{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:38:59Z","timestamp":1761896339502},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,22]],"date-time":"2016-09-22T00:00:00Z","timestamp":1474502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of the randomized present study was to compare the therapeutic efficacy and safety of a combination of sitagliptin, a dipeptidyl peptidase (DPP)\u20104 inhibitor, plus insulin glargine (GL\u2009+\u2009sita) with that of premixed insulin aspart 30 (NOV) for type 2 diabetes (T2D) patients controlled with oral hypoglycemic drugs (HbA1c 7\u00a0%\u20139\u00a0%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010five patients were randomized (1:\u2009\u20091) to the GL\u2009+\u2009sita (n\u2009=\u200933) and NOV (n\u2009=\u200932) groups and were treated with the combination regimen or premixed insulin twice a day for 16\u2009weeks. The primary endpoint was mean change in HbA1c. Secondary endpoints included fasting blood glucose, blood glucose profiles (seven time points), rate of achieving target HbA1c (&lt;7\u00a0% or \u22646.5\u00a0%), insulin dose, incidence of hypoglycemia, and body weight.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 16\u2009weeks, there was no significant difference in HbA1c between the two groups, although more patients achieved HbA1c &lt;7.0\u00a0% in the GL\u2009+\u2009sita group. There was a significant difference in body weight changes between the GL\u2009+\u2009sita and NOV groups (\u22120.45 vs 1.52\u2009kg, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001). Mean plasma glucose and the mean amplitude of glycemic excursion were significantly lower in the GL\u2009+\u2009sita than NOV group (<jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.005), as was the incidence of symptomatic hypoglycemia (2.85\u00a0% vs. 13.3\u00a0%, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The combination of GL\u2009+\u2009sita greatly improved HbA1c in T2D patients (HbA1c 7\u00a0%\u20139\u00a0%) with an efficacy that was equal to that of premixed insulin. Thus, GL\u2009+\u2009sita treatment is a viable option for patients who fail to achieve glycemic control using oral hypoglycemic drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12436","type":"journal-article","created":{"date-parts":[[2016,6,3]],"date-time":"2016-06-03T11:53:32Z","timestamp":1464954812000},"page":"502-509","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Efficacy and safety of coadministration of sitagliptin with insulin glargine in type 2 diabetes"],"prefix":"10.1111","volume":"9","author":[{"given":"Ying","family":"Cao","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Nanfang Hospital Southern Medical University  Guangzhou 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