{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:00:36Z","timestamp":1767164436652,"version":"build-2238731810"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Premixed insulins are recommended starter insulins in Chinese patients after oral antihyperglycemic medication (OAM) failure. In the present study, we compared the efficacy and safety of insulin lispro mix 25 (LM25) twice daily (b.i.d.) and insulin lispro mix 50 (LM50) b.i.d. as a starter insulin regimen in Chinese patients with type 2 diabetes mellitus (T2DM) who had inadequate glycemic control with OAMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The primary efficacy outcome in the present open\u2010label parallel randomized clinical trial was change in HbA1c from baseline to 26\u2009weeks. Patients were randomized in a ratio of 1:\u2009\u20091 to LM25 (n\u2009=\u200980) or LM50 (n\u2009=\u200976). A mixed\u2010effects model with repeated measures was used to analyze continuous variables. The Cochran\u2013Mantel\u2013Haenszel test with stratification factor was used to analyze categorical variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the end of the study, LM50 was more efficacious than LM25 in reducing mean HbA1c levels (least\u2010squares [LS] mean difference 0.48; 95\u00a0% confidence interval [CI] 0.22, 0.74;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u00a00.001). More subjects in the LM50 than LM25 group achieved HbA1c targets of &lt;7.0\u00a0% (72.4\u00a0% vs 45.0\u2009%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.001) or \u22646.5\u00a0% (52.6\u00a0% vs 20.0\u2009%;\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u00a00.001). Furthermore, LM50 was more effective than LM25 at reducing HbA1c in patients with baseline HbA1c, blood glucose excursion, and postprandial glucose greater than or equal to median levels (\n                      <jats:italic>P<\/jats:italic>\n                      \u2009\u2264\u20090.001). The rate and incidence of hypoglycemic episodes and increase in weight at the end of the study were similar between treatment groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In Chinese patients with T2DM, LM50 was more efficacious than LM25 as a starter insulin.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/1753-0407.12442","type":"journal-article","created":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T21:26:43Z","timestamp":1467408403000},"page":"575-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of insulin lispro mix 25 with insulin lispro mix 50 as insulin starter in Chinese patients with type 2 diabetes mellitus (CLASSIFY study): Subgroup analysis of a Phase 4 open\u2010label randomized trial"],"prefix":"10.1111","volume":"9","author":[{"given":"Qing","family":"Su","sequence":"first","affiliation":[{"name":"Department of Endocrinology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Affiliated Hospital on Integration of Chinese and Western Medicine Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongting","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Xinqiao Hospital Third Military Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Xinjiang Key Laboratory of Metabolic Disease Research The First Affiliated Hospital of Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng Fei","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Department Lilly Suzhou Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Qian","sequence":"additional","affiliation":[{"name":"Medical Department Lilly Suzhou Pharmaceutical Co. Ltd  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Ying","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism China\u2013Japan Friendship Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0442"},{"key":"e_1_2_8_3_1","volume-title":"IDF Diabetes Atlas","author":"International Diabetes Federation (IDF)","year":"2013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-015-0602-9"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-010-0194-4"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2013.03.022"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.922"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69703-1"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12098"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908292"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.15.6.540"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-9025"},{"key":"e_1_2_8_13_1","first-page":"447","article-title":"Chinese guidelines for the management of type 2 diabetes mellitus (2013 edition)","volume":"6","author":"Chinese Diabetes Society","year":"2014","journal-title":"Chin J Diabetes Mellitus"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2010.03.004"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666010-00003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01035.x"},{"key":"e_1_2_8_17_1","first-page":"27","article-title":"Effectiveness and safety of Humalog Mix 50\/50 versus Humalog Mix 75\/25 in Chinese patients with type 2 diabetes","volume":"11","author":"Zafar MI","year":"2015","journal-title":"Ther Clin Risk Manag"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001003800231"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2010.51.6.845"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc07-1992"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2816"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4402"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/dme.12080"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nutd.2015.21"},{"issue":"1","key":"e_1_2_8_25_1","first-page":"AP182","article-title":"Glycaemic index and glycaemic load of East Asian foods: The INTERMAP Study","volume":"129","author":"Yan L","year":"2014","journal-title":"Circulation"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa075392"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-2412"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2011.03456.x"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.25.2.275"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)12131-1"},{"key":"e_1_2_8_31_1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.2337\/diab.38.6.723","article-title":"Plasma 1,5\u2010anhydro\u2010d\u2010glucitol as new clinical marker of glycemic control in NIDDM patients","volume":"38","author":"Yamanouchi T","year":"1989","journal-title":"Diabetes"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1910"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.27.8.1859"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2008.00897.x"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1701"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2007.07.003"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-2117"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc09-0395"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1710"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2009.01144.x"}],"updated-by":[{"DOI":"10.1111\/1753-0407.12656","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000}}],"container-title":["Journal of Diabetes"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1753-0407.12442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1753-0407.12442","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1753-0407.12442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T20:43:26Z","timestamp":1695501806000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1753-0407.12442"}},"subtitle":["\u4e2d\u56fd2\u578b\u7cd6\u5c3f\u75c5\u60a3\u8005\u4f7f\u7528\u8d56\u812f\u80f0\u5c9b\u7d20\u9884\u6df725\u4e0e\u8d56\u812f\u80f0\u5c9b\u7d20\u9884\u6df750\u4f5c\u4e3a\u80f0\u5c9b\u7d20\u8d77\u59cb\u6cbb\u7597\u65b9\u6848\u7684\u5bf9\u7167\u7814\u7a76(CLASSIFY\u7814\u7a76):\u5f00\u653e\u6807\u7b7e\u7684\u968f\u673a4\u671f\u8bd5\u9a8c\u4e9a\u7ec4\u5206\u6790"],"short-title":[],"issued":{"date-parts":[[2016,9,26]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/1753-0407.12442"],"URL":"https:\/\/doi.org\/10.1111\/1753-0407.12442","archive":["Portico"],"relation":{},"ISSN":["1753-0393","1753-0407"],"issn-type":[{"value":"1753-0393","type":"print"},{"value":"1753-0407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,26]]},"assertion":[{"value":"2015-12-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-06-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-09-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}