{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T22:56:37Z","timestamp":1766012197822},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,9,4]],"date-time":"2016-09-04T00:00:00Z","timestamp":1472947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003711","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST 104\u20102314\u2010B\u2010006\u2010020\u2010MY2"],"award-info":[{"award-number":["MOST 104\u20102314\u2010B\u2010006\u2010020\u2010MY2"]}],"id":[{"id":"10.13039\/501100003711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006578","name":"Chi Mei Medical Center","doi-asserted-by":"publisher","award":["105 CM\u2010TMU\u201002"],"award-info":[{"award-number":["105 CM\u2010TMU\u201002"]}],"id":[{"id":"10.13039\/501100006578","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Population\u2010based data for diabetic hand syndrome (DHS) are limited. The aim of the present epidemiological study was to estimate the overall and cause\u2010specific prevalence and rate ratio (RR) of DHS in patients with diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present study was a cross\u2010sectional study based on a random sample of 57\u2009093 diabetics and matched controls, both identified from Taiwan National Health Insurance claims in 2010. The DHS analyzed in the present study included carpal tunnel syndrome (CTS), stenosing flexor tenosynovitis (SFT), limited joint mobility (LJM), and Dupuytren's disease (DD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The prevalence of overall DHS was estimated at 2472 per 10<jats:sup>5<\/jats:sup> for the diabetics, compared with 1641 per 10<jats:sup>5<\/jats:sup> for the controls, representing a prevalence RR of 1.51 (95\u00a0% confidence interval [CI] 1.39\u20131.64). Stratified analyses further revealed that the significantly increased prevalence of overall DHS was more evident in females than males (1.59 vs 1.36) and was only noted in diabetics aged \u226535\u2009years. Cause\u2010specific analysis suggested that patients with diabetes had the highest prevalence of CTS (1244 per 10<jats:sup>5<\/jats:sup>), followed by SFT (1209 per 10<jats:sup>5<\/jats:sup>), LJM (39 per 10<jats:sup>5<\/jats:sup>), and DD (6 per 10<jats:sup>5<\/jats:sup>). In addition, diabetes was only significantly associated with CTS (RR 1.34; 95\u00a0% CI 1.20\u20131.51) and SFT (1.74; 95\u00a0% CI 1.54\u20131.97).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The prevalence of overall and certain cause\u2010specific DHS was significantly elevated in patients with diabetes in Taiwan.<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12455","type":"journal-article","created":{"date-parts":[[2016,8,3]],"date-time":"2016-08-03T07:53:00Z","timestamp":1470210780000},"page":"622-627","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of hand syndromes among patients with diabetes mellitus in Taiwan: A population\u2010based study"],"prefix":"10.1111","volume":"9","author":[{"given":"Wen\u2010Hsuan","family":"Hou","sequence":"first","affiliation":[{"name":"Cochrane Taiwan Taipei Medical University  Taipei Taiwan"},{"name":"Master Program in Long\u2010Term Care College of Nursing Taipei Medical University  Taipei Taiwan"},{"name":"School of Gerontology Health Management, College of Nursing Taipei Medical University  Taipei Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation Taipei Medical University Hospital  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chung\u2010Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Public Health, College of Medical Cheng Kung University  Tainan Taiwan"},{"name":"Department of Family Medicine Sin\u2010Lau Christian Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u2010Hsuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Family Medicine Sin\u2010Lau Christian Hospital  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang\u2010Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department and Graduate Institute of Public Health, College of Medical Cheng Kung University  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken N.","family":"Kuo","sequence":"additional","affiliation":[{"name":"Cochrane Taiwan Taipei Medical University  Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiu\u2010Nien","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Public Health, College of Public Health China Medical University  Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Fong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine Chi Mei Medical Center  Tainan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,9,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2008.01.038"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(88)80145-X"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-6632(89)90016-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0266-7681(96)80106-9"},{"key":"e_1_2_7_6_1","first-page":"306","article-title":"The diabetic hand: complications of diabetes","volume":"98","author":"Lekholm C","year":"2001","journal-title":"Lakartidningen"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mporth.2010.03.016"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2008.12.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.1993.tb00729.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.1999.02.536"},{"key":"e_1_2_7_11_1","first-page":"139","article-title":"Limited joint mobility of the hand: Prevalence and relation to chronic complications in non\u2010insulin\u2010dependent diabetes mellitus patients","volume":"92","author":"Lu YC","year":"1993","journal-title":"J. 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