{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T20:20:52Z","timestamp":1781900452811,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,9,13]],"date-time":"2016-09-13T00:00:00Z","timestamp":1473724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Diabetes"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Type 2 diabetes mellitus (T2DM) is a significant burden in China, where approximately 114 million patients have been diagnosed with diabetes. Chinese patients present with prominent \u03b2\u2010cell failure, with resulting deficiency in insulin secretion, particularly early phase insulin secretion leading to postprandial hyperglycemia. Sitagliptin, a selective once\u2010daily oral dipeptidyl peptidase\u20104 inhibitor, has been shown to improve glycemic control as monotherapy and in combination with other antihyperglycemic agents, including sulfonylureas and metformin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter randomized double\u2010blind placebo\u2010controlled study conducted in China. The study assessed the safety and efficacy of the addition of sitagliptin 100\u2009mg once daily versus placebo on changes from baseline at Week 24 in HbA1c, fasting plasma glucose (FPG) and 2\u2010h post\u2010meal glucose (PMG). Patients were aged 18\u201379\u2009years, had T2DM with inadequate glycemic control, and were taking a sulfonylurea, with or without metformin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 24\u2009weeks, sitagliptin reduced HbA1c, FPG, and 2\u2010h PMG significantly more than placebo (between\u2010treatment differences: \u22120.61\u00a0%, \u221216.8\u2009mg\/dL, and \u221232.9\u2009mg\/dL, respectively; <jats:italic>P<\/jats:italic>\u2009&lt;\u00a00.001 for all). The addition of sitagliptin was generally well tolerated, with a comparable incidence of adverse events and drug\u2010related adverse events in both treatment groups. The sitagliptin group had a higher incidence of symptomatic hypoglycemia than the placebo group (25\/248 [10.1\u00a0%] vs 13\/249 [5.2\u00a0%], respectively; <jats:italic>P<\/jats:italic>\u2009=\u20090.042).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sitagliptin 100\u2009mg once daily significantly improved glycemic control in Chinese patients with T2DM who had inadequate glycemic control with sulfonylurea, with or without metformin therapy. The addition of sitagliptin was generally well tolerated. (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link>: NCT01590771).<\/jats:p><\/jats:sec>","DOI":"10.1111\/1753-0407.12456","type":"journal-article","created":{"date-parts":[[2016,8,9]],"date-time":"2016-08-09T00:18:00Z","timestamp":1470701880000},"page":"667-676","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Randomized trial assessing the safety and efficacy of sitagliptin in Chinese patients with type 2 diabetes mellitus inadequately controlled on sulfonylurea alone or combined with metformin"],"prefix":"10.1111","volume":"9","author":[{"given":"Jianming","family":"Ba","sequence":"first","affiliation":[{"name":"Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Han","sequence":"additional","affiliation":[{"name":"Shengjing Hospital of China Medical University  Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyue","family":"Yuan","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University  Zhenjiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"Mo","sequence":"additional","affiliation":[{"name":"Xiangya Hospital of Central South  Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changyu","family":"Pan","sequence":"additional","affiliation":[{"name":"Chinese PLA General Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wu","sequence":"additional","affiliation":[{"name":"Merck &amp; Co. Inc.  Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Merck &amp; Co. Inc.  Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary E.","family":"Hanson","sequence":"additional","affiliation":[{"name":"Merck &amp; Co. Inc.  Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Engel","sequence":"additional","affiliation":[{"name":"Merck &amp; Co. Inc.  Kenilworth New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Ravi","family":"Shankar","sequence":"additional","affiliation":[{"name":"Merck &amp; Co. Inc.  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