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Many studies have demonstrated that the prevalence of PAD in patients with diabetes mellitus (DM) is higher than in non\u2010diabetic patients. In diabetic patients, PAD occurs early with rapid progression, and is frequently asymptomatic. Multiple metabolic aberrations in DM, such as advanced glycation end\u2010products, low\u2010density lipoprotein cholesterol, and abnormal oxidative stress, have been shown to worsen PAD. However, the role of DM in PAD is not completely understood. 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